纳米HA/PA6复合材料的体外生物活性

IN VITRO BIOACTIVITY OF PA6 AND NANO-HA/PA6 COMPOSITE

研究了PA6和纳米HA/PA6复合材料在模拟体液(SBF)中的行为变化,用IR,XRD,SEM和EDS等手段对材料的表面变化进行了分析,讨论了PA6和纳米HA/PA6复合材料的稳定性、亲水性和生物活性。结果表明:在SBF中PA6的吸水率大概在6%左右,纳米HA/PA6复合材料的吸水率有少量下降,PA6和纳米HA/PA6复合材料出现一定的溶解和降解。在SBF中,PA6表面形成Ca,P化合物中的Ca/P比例为1.12,与HA的理论值1.67有一定的差别;HA/PA6复合材料在其表面形成了HA沉积物和碳酸取代的磷灰石沉积物,Ca/P逐步变化为1.67,表现出较好的生物活性。复合材料表面沉积的HA和原来合成的HA具有相近的结晶形貌,该复合材料可作为优良的骨修复填充材料和组织工程支架材料。

The in vitro bioactivities of PA6 and nano-HA/PA6 were studied in SBF(simulated body fluid). The results show that PA6 was not bioactive in SBF, and Ca-P compound is slowly deposited on the surface of PA6, but it was not HA. Nano-HA/PA6 composite was chemically active in SBF, and dissolution and deposition of Ca, P ions happened during the culture in SBF. The Ca-P precipitate on the surface of HA/PA6 composite surface was carbonated-apatite. Its weight lost by about 2 % every week. This kind of composite could be one of the best potential bioactive materials for load-bearing bones, substitution or as bioengineering material.