梗阻性黄疸大鼠可溶性Fas与肝肾功能改变的关系

Relationship between soluble Fas and liver or renal insufficiency in obstructive jaundice rats

目的 :探讨可溶性Fas(sFas)与梗阻性黄疸大鼠肝肾功能损害的关系。方法 :将雄性SD大鼠 36只随机分为对照组 (A组 )、胆总管结扎节第 7天组 (B组 )和第 2 1天组 (C组 ) ,每组 1 2只。分别检测各组血清胆红素、ALT、白蛋白、肌酐、尿素氮和sFas。光镜观察肝肾组织的病理改变。结果 :B组胆红素、ALT和sFas较A组显著升高 (P <0 .0 1 ) ;C组胆红素、ALT、肌酐、尿素氮和sFas较A组显著升高 (P <0 .0 1 )。B组和C组部分肝细胞和肾小管上皮细胞肿胀和坏死 ,C组较严重。结论 :sFas与梗阻性黄疸大鼠肝肾功能损害相关 。

Objective:To evaluate the relationship between soluble Fas(sFas) and liver or renal insufficiency in obstructive jaundice rats.Methods:Thirty six male SD rats were randomized into control(group A),ligation of common bile duct for seven day(group B) and for twenty one day(group C). The level of serum total bilirubin(TB),ALT,albumin,creatine(Cr),blood urea nitrogen(BUN) and sFas were determined. The pathologic changes of the liver and kidney tissue were observed.Results:The content of serum TB,ALT and sFas in group B were higher than that in group A(P<0.01). The serum TB,ALT,Cr,BUN and sFas were increased significantly(P<0.01). Necrosis of some hepatocyte and renal epithelial cells were found in group B and more severe in group C.Conclusion:The sFas levels positively correlate with hepatic and renal dysfunction and it may play roles through apoptosis of the liver and kidney cells in obstructive jaundice.