神经纤维对外加均匀电场刺激的响应

Response of a Nerve Fibers Exposed by Uniform Applied Electrical Field

为了研究外加均匀电场对神经纤维的影响,基于电缆模型,以有限长度的有髓鞘神经纤维为研究对象,通过理论推导,分析了均匀电场刺激下细胞相对跨膜电位的变化机理,得出了细胞相对跨膜电位与细胞轴向不同位置的定量关系.仿真结果证明了理论分析的正确性,证明神经纤维中各点对均匀电场的响应不同,其结论与前人实验结果吻合.

In this paper,the investigation on the influence of the exterior symmetrical electrical field to nerve fiber is the main focus.When the body is exposed to an approximately uniform applied electrical field, physiological changes will happen necessarily. So it is significant for us to study the electrical stimulation of a cell in uniform applied electrical field. Based on the cable model and theoretical analysis, taking the myelinated nerve fiber with limited length as the research object, this paper analyzes the principle of a nerve fiber' response stimulated by uniform applied electrical field, and derives the relationship curve of the relative transmembrane potential to different axial sites of the axon. The simulation results testify the conclusions which are derived from theoretical analysis prove that the responses to the electrical field in different place of the nerve fiber are not the same coincide with the experiment results previously taken.