摘要
目的 :观察神经降压素 (NT)在脑血管病 (CVD)发生、发展中的变化 ,为脑血管病的诊断、治疗效果的判断和预后寻找有效指标 .方法 :用放免测定方法动态观察 1 5 9例CVD患者急性期、恢复期血浆中NT含量 .结果 :脑出血 (CH)患者急性期血浆NT水平峰值为 (6 3.37± 2 7.5 4 )ng/L ,与对照组(4 6 .75± 5 .1 5 )ng/L比较有显著升高 (P <0 .0 5 ) ;CH患者 30d后血浆中NT含量与对照组比较仍然维持在较高水平 ;但脑梗死 (CI)患者急性期血浆NT水平峰值为 (38.6 9± 1 1 .73)ng/L ,明显低于对照组NT(4 6 .75± 5 .1 5 )ng/L水平 ,发病 1 0d后血浆中NT含量与对照组比较已无显著性差异 (P >0 .0 5 ) .结论 :NT在CVD的发生发展中可能具有重要作用 ,动态观察血浆中NT含量的变化对于判断CVD的变化可能有一定的帮助 .
AIM: To explore the role of plasma neurotensin (NT) change in the development of cerebral vascular diseases (CVD). METHODS: The content of plasma NT was measured by radioimmunoassay in 159 patients with CVD during acute and recovery phases. RESULTS: The peak value of plasma NT concentrations in acute phase were significantly increased in cerebral hemorrhage (CH, 63.37±27.54) ng/L, P <0.05, compared with that of control group (46.75±5.15) ng/L. The concentrations of plasma NT 30 d after the onset of CH were still higher than those in control group ( P <0.05). But the peak value of plasma NT concentrations in patents with cerebral infarction (CI, 38.69± 11.73) ng/L, P <0.05 were lower than those in control group (46.75±5.15) ng/L, P <0.05. There was not difference in NT concentrations between patients with CI 10 d after the onset and control group ( P >0.05). CONCLUSION: NT may play some important roles in the development of CVD and dynamical observation of the changes in plasma NT may be of some help in assessing the changes of CVD.
出处
《第四军医大学学报》
北大核心
2004年第7期650-652,共3页
Journal of the Fourth Military Medical University
关键词
脑血管病
脑出血
脑梗死
神经降压素
cerebral vascular disease
cerebral hemorrhage
cerebral infarction
neurotensin