脑血管病发生发展中神经降压素的变化

Significance of changes in neurotensin in development of cerebral vascular diseases

目的 :观察神经降压素 (NT)在脑血管病 (CVD)发生、发展中的变化 ,为脑血管病的诊断、治疗效果的判断和预后寻找有效指标 .方法 :用放免测定方法动态观察 1 5 9例CVD患者急性期、恢复期血浆中NT含量 .结果 :脑出血 (CH)患者急性期血浆NT水平峰值为 (6 3.37± 2 7.5 4 )ng/L ,与对照组(4 6 .75± 5 .1 5 )ng/L比较有显著升高 (P <0 .0 5 ) ;CH患者 30d后血浆中NT含量与对照组比较仍然维持在较高水平 ;但脑梗死 (CI)患者急性期血浆NT水平峰值为 (38.6 9± 1 1 .73)ng/L ,明显低于对照组NT(4 6 .75± 5 .1 5 )ng/L水平 ,发病 1 0d后血浆中NT含量与对照组比较已无显著性差异 (P >0 .0 5 ) .结论 :NT在CVD的发生发展中可能具有重要作用 ,动态观察血浆中NT含量的变化对于判断CVD的变化可能有一定的帮助 .

AIM: To explore the role of plasma neurotensin (NT) change in the development of cerebral vascular diseases (CVD). METHODS: The content of plasma NT was measured by radioimmunoassay in 159 patients with CVD during acute and recovery phases. RESULTS: The peak value of plasma NT concentrations in acute phase were significantly increased in cerebral hemorrhage (CH, 63.37±27.54) ng/L, P <0.05, compared with that of control group (46.75±5.15) ng/L. The concentrations of plasma NT 30 d after the onset of CH were still higher than those in control group ( P <0.05). But the peak value of plasma NT concentrations in patents with cerebral infarction (CI, 38.69± 11.73) ng/L, P <0.05 were lower than those in control group (46.75±5.15) ng/L, P <0.05. There was not difference in NT concentrations between patients with CI 10 d after the onset and control group ( P >0.05). CONCLUSION: NT may play some important roles in the development of CVD and dynamical observation of the changes in plasma NT may be of some help in assessing the changes of CVD.