青、老年期大肠癌临床病理学特征探讨

Study of clinicopathological characters of young and aged patients with colorectal cancer

目的 探讨青、老年期大肠癌的临床病理学特征 ,以提高其诊治水平。方法 比较 2 4例青年期大肠癌(≤ 30岁 )和 5 9例老年期大肠癌 (≥ 6 0岁 )在发病部位、大体类型、组织学类型和淋巴结转移等临床特征的对应关系 ,分析两组之间的差异。结果 青年期大肠癌发生在直肠 70 .8% (1 7/ 2 4 ) ,70 .6 %位于腹膜返折以下 ;浸润型者占 75 .0 % ,组织学分型低分化粘液细胞癌占 79.2 % ,侵犯浆膜者占 70 .8% ,淋巴结转移者为 6 6 .7% ,这些特点与老年期大肠癌相比差异均具有非常显著性意义 (P<0 .0 1 )。青年期大肠癌预后极差 ,五年生存率 2 0 .8% (5 / 2 4 )。结论 青年期大肠癌有一系列不同于老年的临床病理学特生 ,提高对这些特征的认识 。

Objective To study the clinicopathological characters of the young and aged patients with colorectal cancer in order to improve the diagnostic and therapeutic levels.Methods The relationship of the clinicopathological characters in position,type,histological type,lympyh node metastasis between 24 cases of young patients(≤30 years)and 59 elderly patient(≥60 years) with colorectal cancer was.Differences between the two groups were compared.Results Among the young colorectal cancer,70.8%(17/24) were found in rectum,70.6% were below peritoneum reflex,75.0% were invasive type,79.2% were low differentiated mucinous adenocarcinoma in histological type.Serosa was involved in 70.8% and lymphatic metastasis was found in 66.7% of the patients.There characters were significant different from the colorectal cancer in aged patients( P <0.01).The young colorectal cancer has a bad prognosis and the 5 year survival rate was 20.8%(5/24).Conclusion Some clinicopathological characteristics of the young patients with colorectal cancer were different from those of the elderly patients.Early diagnosis and therapeutic effects depend on realizing to these clinical pathologicocharacteristics.