β淀粉样蛋白、白细胞介素-1β在脑梗死患者血清中的含量和临床意义

Serum levels and clinical significance of amyloid β-protein and interleukin-1β of patients with cerebral infarction

目的 探讨 β淀粉样蛋白 (Aβ)、白细胞介素 1β(IL 1β)在脑梗死发生、发展中的作用。方法 用放射免疫分析法检测 30例脑梗死患者发病后 3～ 5d、10～ 14d和 30例正常对照血清Aβ、IL 1β水平。 结果 脑梗死组发病后 3～ 5d血清Aβ、IL 1β水平明显高于 10～ 14d ,后者明显高于对照 ;脑梗死组发病后 3～ 5d血清Aβ与IL 1β水平呈正相关 ,两者均与梗死灶体积、神经功能缺损程度呈正相关。结论 Aβ、IL 1β参与脑梗死发生、发展 ,干扰两者产生和作用途径可减轻脑缺血损伤。

Objective To explore the effects of amyloid β-protein(Aβ)and interleukin-1β(IL-1β) on the occurrence and development of cerebral infarction(CI).Methods The serum levels of Aβ and IL-1β were detected by radioimmunoassay in 30 patients with CI within 3～5 days and 10～14 days after attack and 30 normal controls.Results The serum levels of Aβ and IL-1β of patients with CI within 3～5 days after attack were higher than those within 10～14 days with significant differences.The serum levels within 10～14 days were higher than those of normal controls.There was positive correlation between the serum levels of Aβ and IL-1β.The serum levels of Aβ and IL-1β of patients with CI within 3～5 days after attack were positively correlated with the volume of infarcts as well as the degree of deficiency of the nervous functions.Conclusion Aβ and IL-1β are involved in the occurrence and development of CI and can be used to assess the prognosis and therapeutic effect of CI.Maybe we can alleviate brain damage after cerebral ischemia by interferring with their production and effects.