肝得健和甘利欣对老年癌症化疗患者肝功能保护作用的自身对照研究

Auto-control study on the impact of liver function of senile patients with malignant tumor receiving chemotherapy alone or chemotherapy combined with Essentiale and GanLiXin

对 2 8例化疗药物性肝功能异常的老年癌症患者 ,再次按原方案化疗时加用肝得健和甘利欣护肝治疗 ,从而形成自身对照研究。确定上述两种治疗方式对肝功能的影响。护肝治疗方法 :肝得健 2 0mL/d、甘利欣 15 0mg/d ,平均用药 13d。结果单纯化疗组与化疗 +护肝治疗组比较 ,肝功能损害发生率明显高 ,Ⅰ～Ⅳ度肝功能损害发生率分别为 64 2 9%和 2 6 87% ,χ2 =11 75 ,P <0 0 0 1;其中Ⅱ～Ⅳ度肝功能损害 2组分别为 7例、3例 ,经秩和检验证明 ,两组肝功能损害程度分布上差异有统计学意义 ,P <0 0 0 1。初步研究结果提示 。

The auto-control study on liver function was performed for 28 senile patients with malignant tumor receiving chemotherapy alone or chemotherapy combined with Essentiale (20 mL/d) and GanLiXin (150 mg/d) for about 13 d.Comparing the results of the group of chemotherapy alone with that of the group of chemotherapy combined with Essentiale and GanLiXin, the occurrence of liver function impairment was higher and the impairment degree was more serous in the group of chemotherapy alone. The impairment of liver function withⅠ～Ⅳ degrees for these two groups were 64.29% and 26.87% respectively, χ 2=11.75,P<0.001. A rank sum test to analyze the distribution of impairment degree showed that there was a significant difference between these two groups,P<0.001.In conclusion,Essentiale and GanLiXin are effective medicines in preventing and treating liver function impairment by chemotherapy for senile patient with malignant tumor.