射频治疗在局部晚期非小细胞肺癌综合治疗中的作用

Preliminary Analysis of Radiofrequency Ablation in Synthetic Therapy of Locally Advanced Non-small Cell Lung Cancer

目的:探讨射频治疗在局部晚期非小细胞肺癌综合治疗中的作用。方法:随机将不能切除的Ⅲ期非小细胞肺癌的患者分别纳入综合组和常规组,常规组给予放疗和化疗;综合组在放化疗的基础上加原发灶射频治疗。结果:60例患者进入研究。综合组KPS改善率明显优于常规组(62.07%,21.42%;P=0.02);原发灶局部复发率综合组显著低于常规组(17.2%,42.9%;P=0.017);中位生存期综合组15个月,常规组14个月;1、2年生存率综合组稍高于常规组(78.65%,60.29%;39.84%,27.83%),但两组间比较无统计学意义。结论:射频治疗可有效地降低不可切除的Ⅲ期非小细胞肺癌的局部复发率,改善患者功能状态;但无明显提高不可切除的Ⅲ期非小细胞肺癌1、2年生存率。

Objective: The aim of this study was to evaluate clinical significance of combined chemoradiotherapy and RFA(RFA), performed by using a clustered electrode needle, in the treatment of locally advanced non-small cell lung cancer. Methods: The locally advanced lung cancer were randomized into synthetic group and conventional group. The conventional group received conventional chemoradiotherapy, while the synthetic group received combined chemoradiotherapy and RFA of primary lesion. Results: 60 patients were enrolled. The rate of improvement of KPS for patients in the synthetic group was superior to that patient in the conventional group (62.07% v 21.42%; P=0.02) The local recurrent rate in combined chemoradiotherapy and RFA was less than that in conventional chemoradiotherapy (17.2% v 42.9%; P=0.017). Median survival times were 14 months in the conventional chemoradiotherpy and 15 months in the combined chemoradiotherpy and RFA. There was better one year survival rates and two year survival rates for the combined chemoradiotherpy and RFA comparing with the conventional chemoradiotherpy (78.65% v 60.29%; 39.84% v 27.83% respectively), but no statistically differences. Conclusion: Combined chemoradiotherapy and RFA by EVB electrode needle can decreased local recurrence and improved performance for locally advanced non-small cell lung cancer. But the effect of combined chemoradiotherapy RFA on one year survival rate and two year survival rate was not significant.