正常成人多层螺旋CT灌注成像的脑血流动力学研究

The cerebral hemodynamics study by using multislice CT perfusion imaging in normal adult

目的 探讨多层螺旋CT灌注成像 (MSCTPI)技术在正常人脑血流动力学中的应用。方法 选择 30例正常成年人行常规头颅CT平扫后 ,再行MSCTPI检查。在常规轴面CT扫描后选取基底节及其相邻层面 ,经肘静脉团注对比剂 ,同时开始连续 4 0s的双层动态扫描 ,重建的 80幅动态图像使用CT脑灌注软件包进行处理 ,获得灌注图像 ,测量所选脑内感兴趣区的血流量、血容量及达峰时间 ,并对其进行定量分析。结果 MSCTPI显示正常成年人脑灰质灌注高于脑白质 ,脑灰质的平均血流量、平均血容量、达峰时间分别为 (5 0 6± 9 0 )ml·min-1·10 0 g-1、(5 7 8± 9 1)ml·min-1·10 0 g-1、(10 6± 1 6 )s,脑白质分别为 (2 2 7± 8 6 )ml·min-1·10 0 g-1、(30 8± 9 8)ml·min-1·10 0g-1、(12 9± 2 6 )s。结论 MSCTPI技术为测量脑血流动力学指标提供了一种新的影像学方法。

Objective To explore the application of multislice CT perfusion imaging (MSCTPI) in normal adult cerebral hemodynamics. Methods Routine CT was performed in 30 normal adults,then MSCTPI study was made by selecting the basal ganglia slice and its adjacent slice.The contrast material was bolus injected through antecubital vein,while two layers of dynamic scans were performed for 40 seconds.These 80-slice dynamic images were processed with the CT perfusion software package.Cerebral blood flow (CBF),cerebral blood volume (CBV),and time to peak (TP) were measured within the specific regions of interest (ROI) of the brain,and quantitative analysis was performed. Results A gradient of perfusion between gray matter and white matter was showed on MSCTPI in normal adults.CBF,CBV,and TP were (50.6±9.0) ml·min -1·100 g -1,(57.8±9.1) ml·min -1·100 g -1,and (10.6±1.6) s,respectively in the gray matter,(22.7±8.6) ml·min -1·100 g -1,(30.8±9.8)ml·min -1·100 g -1,and (12.9±2.6) s,respectively in the white matter. Conclusion MSCTPI provided a new imaging method for measuring the cerebral hemodynamics.