前列腺癌的MR波谱定量分析:与系统穿刺活检病理对照研究

Quantitative analysis of prostate adenocarcinoma by magnetic resonance spectroscopy: correlation study with systemic biopsy

目的 用MR波谱 (MRS)分析方法定量评价前列腺癌的代谢改变。方法 18例超声引导下系统穿刺活检证实的前列腺癌患者在MRS代谢图上标记出活检取材位置 ,分别测量各个位置 (胆碱 +肌酸 ) /枸橼酸盐 [(Cho +Cre) /Cit]的比值。计算穿刺病理结果为癌处的 (Cho+Cre) /Cit比值的平均值。结果 18例患者共系统穿刺 2 0 4针 ,其中 10 6针为前列腺癌。此 10 6处 (Cho +Cre) /Cit比值的平均值为 2 5 3± 1 0 2。肿瘤区域与非肿瘤区域的 (Cho +Cre) /Cit比值差异有非常显著性意义 (P <0 0 1)。但肿瘤组与非肿瘤组的 (Cho +Cre) /Cit比值有部分重叠 ,如果以 0 86为分界值 ,则两组之间有 10 9% (2 0 / 184 )的交叉。结论 前列腺癌的代谢改变可用MRS进行定量评价。

Objective To quantitatively evaluate the metabolic changes of prostate adenocarcinoma using magnetic resonance spectroscopy (MRS).Methods Eighteen patients of prostate cancer proved by ultrasound guided systemic biopsy were enrolled in this study.All the puncture locations were marked and the corresponding (Choline+Creatine)/Citrate ratios were calculated on the basis of the MRS metabolic map.Results 204 samples were obtained and 106 of them were diagnosed as cancer.The average (Cho+Cre)/Cit ratio in the 106 positions was 2.53±1.02.The (Cho+Cre)/Cit ratio of cancer area was statistically higher than that of noncancerous area (F=8.64, P<0.01).But there was overlap of the (Cho+Cre)/Cit ratio between the two groups.If take 0.86 as the threshold, there would be 10.9% overlap between the malignant and nonmalignant areas.Conclusion The metabolic changes of the prostate adenocarcionma could be quantitatively evaluated by MRS.