老年2型糖尿病患者空腹血清真胰岛素水平与血脂的关系

The relationship between serum fasting true insulin and lipids in the elderly patients with type 2 diabetes mellitus

目的 探讨老年 2型糖尿病 T2 DM(T2 DM)患者空腹血清真胰岛素水平与血脂的关系。方法 对正常糖耐量 (NGT)组 50例、T2 DM组 87例 T2 DM伴原发性高血压 (T2 DM+EH)组 76例应用 BA- ELISA法测定空腹血清真胰岛素 (TI) ,应用放射免疫法测定免疫反应胰岛素 (IRI) ,应用酶法检测血脂。结果 T2 DM组和 T2 DM+EH组甘油三酯 (TG)与 TI呈显著正相关 (P<0 .0 1 ) ,高密度脂蛋白 (HDL- C)在 T2 DM和 T2 DM+EH组与 TI呈负相关 (P<0 .0 5) ,TG、HDL- C与 IRI均无相关性 (P>0 .0 5)。结论 老年 T2 DM患者空腹血清 TI水平与脂代谢异常有关 ,空腹血清TI水平的升高会引起 TG的升高和 HDL-

Objective To explore the relationship between serum fasting true insulin (TI) and lipids in elderly patients with type 2 diabetes mellitus (T2DM). Methods TI, fasting serum immunoreactive insulin (IRI) and blood lipids were determined with BA-ELISA, radioimmunoassay method and enzyme method, respectively, in the normal glucose tolerance group (50 cases), T2DM group (87 cases) and T2DM complicated with essential hypertension (T2DM+EH) group (76 cases). Results In T2DM and T2DM+EH groups, TI has statistically significant positive correlation with TG( P <0.01)and significant negative correlation with HDL-C ( P <0.05), while IRI has no relation with TG and HDL-C( P >0.05).Conclusions Serum fasting TI is associated with dyslipidemia in T2DM, and the the increase of TI can elevate TG and decrease HDL-C.