细胞因子与高血压病心功能不全的相关性研究

Study on the relationship between essential hypertension complicated with cardiac dysfunction and cytokines

目的 观察高血压病 (EH)心衰患者细胞因子白细胞介素 6(IL- 6)、白细胞介素 8(IL- 8)、肿瘤坏死因子 α(TNF- α)、γ干扰素 (IFN- γ)及 Apo- 1 / Fas的变化 ,分析心功能改变与细胞因子相关性 ,以期为临床应用更有效的干预治疗提供理论依据。方法 采用 ELISA法检测 60例高血压病患者和 2 0例正常对照组血清各炎性细胞因子浓度 ,并应用彩色多普勒超声心动图测定其左室收缩及舒张功能 ,分析心功能改变与细胞因子相关性。结果 与正常对照组比较 EH组的血清细胞因子含量明显升高 ,增高的程度与心衰的严重程度相一致 ,心功能不全组间比较也有明显差别 ,EH组收缩功能减退及舒张功能减退与炎性细胞因子的增高密切相关。结论 高血压病心衰患者存在着细胞因子的过度激活及心肌细胞的凋亡 ,并与心衰程度加重密切相关 。

Objective To study the changes of the IL-6, IL-8, TNF-α, IFN-γ, Apo-1/Fas of the patients with the essential hypertension (EH group) complicated with cardiac dysfunction, and to explore the relation of cardiac function with cytokines.Methods The serum levels of cytokines were assayed with ELISA in 60 hypertensive cases and 20 normal controls and the left ventricular systolic and diastolic functions were measured by color Doppler. At the same time, the relation of cardiac function with cytokines was analyzed. Results Compared with control group, the serum levels of cytokines increased significantly, and the degree of increase was consistent with heart failure in EH group. There also existed correlation between the decrease of heart function and the increase of cytokine levels in EH group.Conclusions In patients with essential hypertension complicated with cardiac dysfunction, there were excess activation of cytokines and cardiac cell apoptosis that were consistent with heart failure, which played an important role in the occurrence and development of cardiac dysfunction.