TF-1细胞凋亡相关基因19在桥本病甲状腺细胞中的表达

Expression of TF-1 cell apoptosis-related gene 19 in the thyrocytes of Hashimoto′s thyroiditis

探讨新的凋亡相关蛋白TFAR19在桥本病 (HT )甲状腺组织中是否表达。结果显示TFAR19在正常甲状腺组织中几乎未见表达 ,而在HT患者甲状腺细胞中阳性表达 ,提示TFAR19凋亡通路激活可能在HT的发病机制中发挥重要作用。

The expression of TF-1 cell apoptosis-related gene 19 (TFAR19), a novel apoptosis-related protein, in the thyroid tissues of Hashimoto′s thyroiditis (HT) was investigated. TFAR19 expression was barely detectable in normal thyroid tissues, whereas positive expression was found in the thyrocytes of HT patients. The results suggested that the activation of TFAR19 apoptosis pathway may play an important role in the pathogenesis of HT.