甲亢与甲减患者血浆同型半胱氨酸水平和MTHFR基因多态性研究

Study of plasma homocystein level and methylene-tetrahydrofolate reductase (MTHFR) gene polymorphism in the patients with hyper-and hypothyroidism

本研究观察了 5 0名正常人 ,3 2例甲状腺功能减退 (甲减 )患者和 48例甲状腺功能亢进 (甲亢 )患者血浆同型半胱氨酸 (Hcy)水平和 5 ,10 亚甲基四氢叶酸还原酶 (MTHFR)基因的多态性。与正常组相比 ,血浆Hcy水平在甲减组升高 (P <0 .0 1) ,而在甲亢组降低 (P <0 .0 5 ) ;在不同甲状腺功能人群中血浆Hcy水平与FT4水平呈负相关 (r =-0 .3 5 ,P <0 .0 1)。在 3组对象中 ,MTHFR均以C/C基因型为主 ,各基因型 (C/C ,C/T ,T/T)、各等位基因 (C ,T)分布差异无显著性 ,但各组中T/T基因型者血浆Hcy水平均高于同组的其它基因型 (P <0 .0 1)。

Plasma homocystein (Hcy) level and 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism were investigated in 50 normal subjects, 32 cases of hypothyroidism and 48 cases of hyperthyroidism. As compared with normal group, plasma Hcy level was increased in hypothyroidism group (P<0.01) and decreased in hyperthyroidism group (P<0.05). A negative correlation existed between plasma Hcy level and FT 4 level (r=-0.35, P<0.01). Majority of MTHFR genotypes was C/C in 3 groups and there was no distribution difference of allele C or T among 3 groups, but plasma Hcy level was higher in the carriers of genotype T/T than those of the other genotypes C/C or C/T in the same group (P<0.01).