重组人红细胞生成素术前红细胞动员和术后红细胞恢复临床观察

Clinical observation of the RHuEPO effects on mobilizing RBC before surgical operation and recovering RBC after operation

目的 评价重组人红细胞生成素 (宁红欣 )注射液用于外科术前红细胞动员和术后红细胞恢复的临床疗效和安全性。 方法 分别于术前 7d、5d、3d、术日 2 4h内、术后 2d、4d皮下注射宁红欣 6 0 0 0U ,观察临床症状及用药前后患者的血红蛋白、红细胞压积、血小板、血清铁、铁蛋白、肝肾功能的变化情况。 结果 宁红欣治疗组血红蛋白、红细胞压积、红细胞及网织红细胞计数均明显升高 ,术后 10d分别达 (12 5 88± 11 93)g/L、0 4 0± 0 0 4、(4 10± 0 4 5 )× 10 12 /L和 (1 92± 0 72 )× 10 9/L ,与对照组 (117 73± 12 15 )g/L、0 37± 0 0 4、(3 80± 0 5 2 )× 10 12 /L和 (1 6 1± 0 5 1)× 10 9/L比较 ,均为P <0 0 1。血小板、血清铁和铁蛋白均无明显变化 ,肝肾功能未见异常。 结论 宁红欣对围手术期患者的术前红细胞动员和术后红细胞恢复有一定的效果。

Objective To evaluate the therapeutic efficacy and adverse effects of RHuEPO (recombinant uuman erythropoietin) on mobilizing RBC before surgical operation and recovering RBC after operation. Methods Six thousand U RHuEPO were injected through hypodermic on the 7 th day, 5 th day, 3 rd day before operation, the day of operation, and the 2 nd day, 4 th day after operation respectively. The variations of clinical symptoms, Hb, HCT, PLT, serum iron, iron albumen, the functions of liver and kidney were strictly observed, from October 2000 to August 2001. Results The Hb, HCT RBC and Ret cell on postoperative day 10 in RHuEPO group 〔(125.88±11.93)g/L,0.40±0.04, (4.10±0.45)×10 12/L,(1.92±0.72)×109/L〕 were significantly higher than that of the control group 〔(117.73±12.15)g/L?0.37±0.04?(3.80±0.52)×10 12/L,(1.61±0.51)×109/L〕respectively P<0.01. There was no significant change in PLT, serum iron, and iron albumen.Also the functions of liver and kidney remained normal. Conclusions RHuEPO has an effect on mobilizing RBC before operation and recovering it after operation.