二氧化硫对肝脏组织学结构的影响

Sulfur dioxide-induced liver pathology

目的 了解短期二氧化硫吸入对肝脏的损伤作用。方法 采用HE染色和透射电镜观察了二氧化硫染毒后肝脏的病理组织学变化。结果 当用56 mg/m3、112 mg/m3、168 mg/m3的二氧化硫分别对小鼠染毒1周后可引起小鼠明显的肝脏病理改变,HE染色观察发现肝组织中有淋巴细胞、中性粒细胞、单核细胞浸润,并且有明显的肝细胞坏死,呈点状和灶状坏死。电镜观察发现二氧化硫可引起肝脏实质细胞脂肪变、嗜酸颗粒变和坏死。结论 刺激性污染物二氧化硫对呼吸系统以外的脏器如肝脏具有明显的损伤作用。

Objective To investigate effects of short-term sulfur dioxide inhalation to the liver. Methods Haematoxylin and eosin staining (HE) and transmission electron microscopy (TEM) were used to study the pathologic changes in mice liver after sulfur dioxide ( SO2 ) inhalation. Results Exposure to 56 mg/m 3, 112 mg/m 3, 168 mg/m3 SO2 caused increasingly severe liver injuries, as detected by HE staining and TEM. The morphologic changes included spotty necrosis with lymphocyte, monocyte, and neutrophil infiltration, fatty degeneration of hepatocytes with dilatation of rough endoplasmic reticulum and dissociation of ribosomes, as well as degeneration of mitochondria and karyorrhexis. Conclusion SO2 inhalation can cause marked liver injury in experimental settings.