1997～2000年与1988～1996年北京地区儿童1型糖尿病发病率比较

Survey of type 1 diabetes incidence in children from 1997-2000 in Beijing area

目的 了解 1997年～ 2 0 0 0年北京地区儿童 1型糖尿病发病率 ,与 1988～ 1996年的调查结果进行比较。方法 按照世界卫生组织 (WHO)标准的捕获再捕获调查法 ,通过 2个渠道搜集所有 1997年 1月 1日～ 2 0 0 0年 12月 31日新发病的北京地区 15岁以下 1型糖尿病儿童 ,按人口统计资料计算发病率 ,按 2 0 0 0年人口普查公布的结果计算年龄校正的发病率。泊松分布公式计算发病率的可靠性 (95 %可信限 ) ,卡方检验法检验发病率差异的显著性。结果 1997～ 2 0 0 0年间 ,北京地区儿童 1型糖尿病的年发病率波动在 0 75 9/ 10万～ 1 2 15 / 10万之间 ,平均年发病率为 1 0 14 / 10万 ,95 %可信限为 0 98/ 10万～ 1 16 / 10万。与 1988～ 1996年比较 ,年粗发病率差异无显著性 ;按 2 0 0 0年普查资料 ,以年龄矫正后 ,发病率分别为 0 83/ 10万和 0 86 / 10万 ,差异无显著性。年龄比较依然为 10～ 14岁组发病率高 (P =0 0 0 2 )。虽然女性较男性发病率高 ,但与北京地区前述的报告不同 ,男女发病率比较差异无显著性。结论 1997～ 2 0 0 0年北京地区儿童 1型糖尿病平均年发病率为1 0 14 / 10万 ,与 1988～ 1996年调查结果比较未见明显增高。

Objective The incidence of type 1 diabetes varied in different countries, different nations and different regions. This survey was conducted to clarify the incidence of type 1 diabetes of children in Beijing area between 1997 and 2000,to compare and analyze the difference in incidence of type 1 diabetes between the 2 periods of 1988-1996 and 1997-2000. Method According to the criteria of WHO Diabetes Mondial (DIAMOND), data were collected from all the children younger than 15 years of age in Beijing area who had the onset of type 1 diabetes during Jan. 1st, 1997 to Dec. 31st, 2000. Using the capture-recapture methods, 95% confidence intervals of incidence were calculated with Poisson′s distribution formula. The significance of differences was tested with Chi-square method. Results The incidences of type 1 diabetes during 1997-2000 were around 0.76/100 000 to 1.21/100 000. The average yearly incidence was 1.014/100 000 (95% confidence interval was 0.98/100 000-1.16/100 000). There was no significant difference in the incidence between 1988-1996 and 1997-2000, and it showed the same result when the incidences were adjusted by age according to the Chinese population census in 2000 (The incidence was 0.83/100 000 in 1988-1996 and 0.86/100 000 in 1997-2000, respectively). The incidence was higher in 10-14 year-old group than the younger groups ( P =0.002). There was no significant difference between male and female groups, either. Conclusions No significant difference was found between the periods 1988-1996 and 1997-2000 when the average yearly incidence of type 1 diabetes of children in Beijing was compared. These results were different from the other countries′ reports that the incidence of type 1 diabetes was increasing by 3%-5% per annum. There was no significant difference between male and female groups either and there was a higher incidence of type 1 diabetes in 10-14 yr group than the other groups in 1997-2000. Although the life-style of Beijing people changed a lot, it didn′t affect the incidence of type 1 diabetes in children in this area. But since many people migrated to Beijing from other parts ofthe country, the changes in constitutive proportions of population might have some impacts on the results of the survey.