“恶性组织细胞增生症”的TCR-γ基因重排研究

Detection of TCR-γ chain gene rearrangement in malignant histiocytosis

目的 从基因水平探讨“恶性组织细胞增生症 (恶组 )”的瘤细胞属性。方法 用两组针对T细胞受体 (TCR)γ链的通用引物和聚合酶链反应 ,对 2 8例“恶组”的尸检病例进行了TCR γ基因重排的检测。结果 2 8例中 12例 (4 3% )检测出单克隆性TCR γ基因重排。结论 我国西南地区的部分“恶组”病例在基因水平上被证实为外周T细胞淋巴瘤。

Objective To investigate the lineage of the malignant cells in malignant histiocytosis. Methods Polymerase chain reaction with two groups of common primers for TCR-γ gene was used to analyze the malignant cells of 28 autopsied cases of malignant histiocytosis. Results Monoclonal TCR-γ gene rearrangements were detected in 12 out of the 28 samples(43%). Conclusion Most cases diagnosed as malignant histiocytosis in Southwest China seems to be peripheral T-cell lymphomas.