小剂量三尖杉酯碱治疗狼疮肾炎

Low-dosage harringtonine for treating lupus nephritis

目的观察小剂量三尖杉酯碱治疗狼疮肾炎的近期疗效。方法三尖杉酯碱1 mg+生理盐水500 ml静脉滴注,5～7 d为1个疗程,间隔2～3周,总共3～6个疗程。结果12例中临床完全缓解7例(58%),部分缓解5例(42%)。总有效率100%。结论小剂量三尖杉酯碱治疗狼疮肾炎具有疗效高、副作用小、价格低的特点,值得临床应用。

Objective To evaluate the therapeutic effect of low-dose herringtonine in lupus nephritis.Methods Harringtonine1mg,which was dissolved in500ml normal saline,was infused intravenously everyday for5to7days as a single course.The total therapeutic period was consisted of3to6courses.Each course was given every2to3weeks.12patients with lupus nephritis were treated in this study.Results Seven patients(58%)achieved complete clinical remission while5(42%)had partial clinical remission.The overall response rate was100%.Conclusion This study suggests that low-dose harringtonine is an effective therapeutic regimen for lupus nephritis with relatively low toxicity and low price.It has the potential to be used widely in treating lupus nephri-tis.