北京市外来儿童脊髓灰质炎免疫屏障评价

Evaluation on Immune Level of Poliomyelitis in Healthy Floating Children in Beijing

开展对外来儿童脊髓灰质炎 (脊灰 )抗体水平监测 ,对制定适宜的免疫策略 ,保持无脊灰状态具有重要意义。根据北京市外来人口密集程度和地理分布特点 ,共采集 4个区 1～ 14岁外来儿童血标本 337人测定脊灰抗体水平 ,脊灰Ⅰ、Ⅱ、Ⅲ型中和抗体阳性率分别为 98 5 2 %、99 70 %、95 2 5 % ,几何平均滴度 (GMT)分别为 1∶12 3 0 3、1∶10 9 6 5、1∶5 8 88。 1岁、2～ 4岁儿童各型抗体GMT显著高于 5～ 9岁、10～ 14岁儿童。不同地区间计划免疫管理水平和疫苗接种质量存在差距 ,外来儿童脊灰抗体水平仍低于北京市儿童。

To carry out the surveillance on immune level of floating children is an important content for working out a feasible preventive strategy,and it is also essential for keeping the state of polio-free.In 2002,we collected 337 serum specimens from 1-14 year old healthy floating children in four districts of Beijing base on different population density and geographical distribution.The neutralizing antibody positive rates of them were 98.52% for polio Ⅰ,99.70% for polio Ⅱ,95.25% for polio Ⅲ and the GMTs were 1∶123.03,1∶109.65 and 1∶58.88 respectively.The GMTs of age groups of 1 year and 2-4 years were evidently higher than that in age groups of 5-9 years and 10-14 years.The management level of EPI and the quality of vaccine inoculation had distance among the four districts.The GMT level of floating children was still lower than that of Beijing children.