河南省1999～2000年急性弛缓性麻痹病例肠道病毒感染流行病学分析

Epidemiological Analysis of Enterovirus Infection of Actute Flaccid Paralysis Cases in Henan Province in 1999-2000

河南省 1999～ 2 0 0 0年从 10 87例急性弛缓性麻痹 (AFP)病例粪便标本中 ,共分离出 92株脊髓灰质炎 (脊灰 )病毒 (PV)和 70株非脊灰肠道病毒 (NPEV) ,分离率分别为 8 4 6 %和 6 4 4 %。Ⅱ型为PV的主要型别 ,共 4 5株 ,占4 8 91%。NPEV中埃可 (ECHO)病毒 6 5株 ,占 92 86 % ,病毒型别以ECHO11、7、12 为优势血清型。柯萨奇A组病毒(Cox A) 1株 ,柯萨奇B组病毒 (Cox B) 4株。检出PV多在冬春季 ,NPEV流行高峰期在 8～ 10月 ;感染均以小年龄儿童为主。多数肠道病毒 (EV)感染者伴有发热、腹泻或肌肉疼痛等症状。 38例发病 6 0d后仍残留麻痹 ,其中多数为PV感染 ,且未完成全程免疫。EV感染病例临床诊断以格林 巴利综合征和NPEV感染为主。在无脊灰证实以后 。

strains of poliovirus(PV)and 70 strains of non-polio enterovirus(NPEV)were isolated and serotyped from 1087 acute flaccid paralysis(AFP)cases during 1999-2000 in Henan Province. TypeⅡ was the main serotype of PV(45 strains,48.91%)ECHO was the main serotype of NPEV(65 strains,92.86%)types 11,7,12 were the predominant serotypes.Other NPEV viruses,1 strain of Cox.A and 4 strains of Cox.B ,were also isolated.The PV infection mostly occurred in December and January and NPEV infection peak occurred from Augest to October.Enteroviruses (EV) were mainly isolated from children aged 0-4 years.Most AFP cases infected by EV had symptoms of fever,diarrhea or muscular ache.38 cases had residual paralysis after 60 days of disease onset,most of them were infected with PV and had not been full-course immunized.The clinial diagnosis of EV infection cases were mostly GBS and NPEV infection.After having been confirmed of polio-free,we should strengthen the surveillance and study of PV and NPEV.