幽门螺杆菌相关性胃炎的细胞免疫功能的研究

Study on the cell immunity function of Helicobacter pylori-associated gastritis

目的 :探讨细胞免疫在Helicobacterpylori(Hp)相关性胃炎的损伤中的作用。 方法 :检测外周血T淋巴细胞亚群及IL 2、sIL 2R、IL 6、IL 8水平。结果 :病例组与对照组比较 ,CD+ 3 、CD+ 4 和CD+ 4 /CD+ 8比值及血清IL 2水平均显著降低 (P <0 0 1) ,而sIL 2R、IL 6和IL 8水平均显著升高 (P <0 0 1)。结论 :细胞免疫在Hp相关性胃炎的损伤中作用明显 ,检测细胞免疫功能对Hp相关性胃炎的病情监测、疗效观察及预后判定有一定价值。

Objective:To study the effect of cell immunity function on Hp-associated gastritis.Methods:45 pationts with Hp-associated gastritis were detected for the levels of the second cluster of T lymph cell and IL-2,sIL-2,IL-6,IL-8 in venous plasma.Results:The levels of CD + 3,CD + 4 and CD + 4/CD + 8 were significantly lower than that of control group(P<0.01).But the levels of sIL-2R,IL-6 and IL-8 were significantly higher than that of control group(P<0.01).Conclusion:The cell immunity fuction plays an important role in injury of Hp-associated gastritis.