气管夹闭窒息法家兔心脏骤停模型的研究

A rabbit model of sudden cardiac arrest by the method of clipping trachea to asphyxia

目的 用气管夹闭窒息法建立一种稳定的心肺复苏动物模型。方法 家兔呼气末夹闭气管窒息法致心脏停搏 ,夹管后 8min行标准心肺复苏 5min ,观察窒息和复苏期间的MAP与心电图变化。结果 气管夹闭前MAP为 (111± 7)mmHg(1mmHg =0 .13 3kPa) ,夹闭后MAP明显下降时间为 (172± 2 0 )s ,降至 5 0mmHg时间为 (2 2 8± 3 3 )s ,5min时为 (2 7± 12 )mmHg ,7min时为 (8± 4)mmHg ,MAP变化与心电图变化一致 ;自主循环恢复 16例 ,未恢复 2例 ,心肺复苏成功率为 89%。结论 该模型具有稳定、简单、重复性好的特点 ,能够满足心肺复苏实验研究需要。

Objective To establish a stabile normal model of cardio-pulmonary resuscitation by the method of clipping trachea to asphyxias.MethodS Adult health rabbit,clipping trachea at the end of breathe,operating the CPR for 5 min after clipping trachea 8 min,observing the mean artery blood pressure (MAP) and EKG in the period of the asphyxia and CPR.Results In front of clipping trachea,the MAP is(111±7) mm Hg;MAP descenting time in(172±20) ses,MAP declining to 50 mm Hg time in(228±33) ses,5 min MAP is (27±12) mm Hg,7 min MAP is(8±4) mm Hg,the change is the same between the MAP and the EKG.16 examples succeed,and 2 examples fail,success rate 89%.Conclusion That model has the satisfied Operability and Repetition,and need for experiment research of the cardiopulmonary resuscitation.