冠心病患者血清褪黑素的变化

Serum melatonin in patients with coronary heart disease

目的 :研究冠心病患者血清褪黑素 (Melatonin ,MLT)变化 ,了解MLT与冠心病的可能关系 ,观察β 受体阻滞剂对冠心病患者MLT分泌的影响。方法 :用放射免疫分析法测定对照组 2 0例、冠状动脉造影证实冠状动脉高度狭窄的不稳定型心绞痛 (UA)患者 30例 (其中 14例服用 β 受体阻滞剂 )及急性心肌梗死 (AMI)患者33例 (其中 16例服用 β 受体阻滞剂 ) ,清晨 5 :30～ 6 :0 0测血清MLT。分析 3组间血清MLT水平的差异。 结果 :UA组及AMI组血清MLT水平分别为 (2 4 .4 5± 2 0 .80 )、(31.2 2± 2 5 .80 )ng/L ,均明显低于对照组 [(4 7.0 3±2 5 .6 2 )ng/L],差异有统计学意义 (均 P <0 .0 1)。服用与未服用 β 受体阻滞剂的冠心病患者间血清MLT水平差异无统计学意义 (P >0 .0 5 )。结论 :冠心病患者体内血清MLT显著降低 ,β

Objective:To explore the changes of serum melatonin in patients with coronary heart disease (CHD) and the effect of beta-blockers on the secretion of melatonin in CHD patients. Method:Three groups of individuals were studied: ①20 controls; ②30 patients with unstable angina (UA) documented severe coronary heart disease by angiography, 14 of them taking beta-blockers daily in therapeutic dosages; ③33 patients with acute myocardial infarction (AMI), 16 of them taking beta-blockers. Serum samples were collected at 5:30～6:00. Am Melatonin was measured radioimmunologically. Result:The levels of serum melatonin in patients with UA and AMI were significantly lower than controls( 24.45± 20.80) ,( 31.22± 25.80)and( 47.03± 25.62)ng/L respectively (all P< 0.01). Melatonin excretion in patients treated with beta-blockers did not differ significantly from those patients not received beta-blockers.Conclusion:The endogenous levels of serum melatonin were significantly decreased in patients with coronary heart disease.