Langerhans细胞、巨噬细胞、浆细胞、淋巴细胞与胃癌预后的关系

RELATIONSHIP CBETWEEN LANGRHANS CELLS, MACROZPHDAGES,PLASMACYTES, LYMPHOCYTES AND THE PROGNOSIS OF GASTRIC CARCINOMA

本文报道应用免疫组化方法在石蜡切片上对86例胃癌标本进行观察研究。结果表明:胃癌组织中浸润的S—100阳性的Langerhans细胞(LGCs)的密度与患者的性别、肿瘤的大体类型、组织学类型、浸润深度和临床分期间无明显关系,但与其预后关系密切。LGCs较多者其术后生存期较LGCs较少者明显长。这提示LGCs在宿主的抗肿瘤过程中可能具有重要作用。肿瘤中有明显浆细胞或淋巴细胞浸润者,预后亦较好。而巨噬细胞与预后在本实验未显示出明显关系。

Eithty -six paraffin sections of gas flic carcinoma were studied for the presence of Langerhans cells (LGCs) and macrophages by immunohistochemical methods with the use of antibodies against S?100 protein and lysozyme respectively. The results showed no correlation between the density of S?100 protein-positive dLGCs infiltrated in gastric carcinoma and various clinical and morphologic features, including tumor gross appearance, histologic type, depth of invasion, clinical stage and patient's sex .There was good correlation between the density of LGCs and patients's prognosis. Patients with denser infiltration of LGCs, had longer survival time than that in case with slight infiltratlion (P< 0.01) . Patients with more plasmacytes and lymphocytes had better prognosis also. There were no relationships between the density of lysozyme positive macrophages and various clinical and morphologic features and othher criteria of patients's prognosis.