血管性痴呆肾虚血瘀程度与血浆ET、血清NO、HCY、E_2、T含量变化分析

RELATIONS BETWEEN KIDNEY ASTHENIA WITH BLOOD STASIS SYNDROME IN VASCULAR DEMENTIA AND ET, NO, HCY, E_2 AND T

目的 :研究血管性痴呆 (VD)肾虚血瘀型患者血浆内皮素 (ET)、血清一氧化氮 (NO)、同型半胱氨酸(HCY)、雌二醇 (E2 )及睾酮 (T)的变化 ,探讨其机制及其与肾虚血瘀证的关系。方法 :选取本病患者 70例 ,依据肾虚血瘀证候评分分为轻、中、重症组 ,与正常对照组进行ET、NO、HCY、E2 、T比较。结果 :VD各组ET、ET/NO及HCY非常显著高于正常组 (P <0 .0 1) ,NO显著低于正常组 (P <0 .0 1) ,且各组间差异显著 (P <0 .0 0 1) ;女性VD患者E2 水平低于女性正常组 (P <0 .0 5 ) ,男性VD患者E2 、E2 /T高于男性正常组 ,T低于男性正常组 (P <0 .0 5 ) ,男轻症组与中、重症组T比较差异显著 (P <0 .0 5 ) ;VD肾虚血瘀型血瘀证候积分值与ET、ET/NO、HCY呈显著正相关 (P <0 .0 5或P <0 .0 1) ,与NO呈显著负相关 (P <0 .0 1) ,与E2 /T无相关性 (P >0 .0 5 )。结论 :ET、NO、ET/NO、HCY、E2 、T介导了VD肾虚血瘀证型的发生发展 。

Objective:To investigate changes of ET, NO, HCY, E 2 and T and relationship with kidney asthenia with blood stasis syndrome (KABSS) in vascular dementia. Method: According to TCM standard of KABSS, 70 patients were selected and divided into three groups (the mild, moderate and severe groups). Thirty healthy aged people were selected as a control. Results: ① The levels of ET,HCY and ET/NO in the three groups with vascular dementia were significantly higher than those in the control group(P<0.01). The serum level of NO in the three groups was significantly lower than that in the control group (P<0.01). And the levels of ET,NO,HCY,E 2,T among these groups were significant different (P<0.01). ② The level of E 2 in female patients decreased significantly,which compared to that in the control group(P<0.05). Nevertheless, the level of E 2 in male patients was significantly higher than that in the control group and the level of T in male patients was remarkable lower than that in the male control group(P<0.05). The level of T in the mild syndrome group was higher than that in the severe syndrome group. ③The amount of integral blood stasis syndrome has a significant positive correlation with ET, ET/NO, HCY, and has a notable negative correlation with NO, but has no correlation with E 2/T. Conclusion: The disturbance releasing of ET,NO,HCY,E 2 and T may be related to the occurrence and development of the KABSS of VD. These indexes can serve as a reference to judge the existence of KABSS.