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Survivin在膀胱癌中的研究进展 被引量:3

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摘要 Survivin是凋亡抑制蛋白家族成员之一 ,几乎在所有人类肿瘤中都有不同程度的表达 ,在正常分化成熟的组织中不表达 (胸腺、生殖腺除外 ) ,具有调节细胞周期、抑制细胞凋亡的作用。它是一个有潜在价值的肿瘤标记物和肿瘤治疗的新靶点 ,本文就其生物学特点及在膀胱癌中的研究现状进行综述。
机构地区 [
出处 《国外医学(泌尿系统分册)》 2004年第3期338-341,共4页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
关键词 膀胱肿瘤
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参考文献21

  • 1Holcik M.The IAP proteins.Trends in Genetics,2002,18(10),537-8
  • 2Suzuki A,Ito T,Kawano H,et al.Survivin initiates procaspase 3/p21 complex formation as a result of interaction with Cdk4 to resist Fas-mediated cell death.Oncogene,2000,19,1346~53
  • 3Lehner R,Lucia MS,Jarboe EA,et al.Immunohistochemical localization of the IAP protein survivin in bladder mucosa and transitional cell carcinoma.Appl Immunohistochem Mol Morphol,2002,10(2),134~8
  • 4Rodriguez JA,Span SW,Ferreira CG,et al.CRM1-mediated nuclear ex-port determines the cytoplasmic localization of the antiapoptotic protein survivin.Exp Cell Res,2002,275(1),44~53
  • 5Blanc-Brude OP,Mesri M,Wall NR,et al.Therapeutic targeting of the survivin pathway in cancer:Initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis.Clin Cancer Res,2003,9(7),2683~92
  • 6Ito T,Shiraki K,Sugimoto K,et al.Survivin promotes cell proliferation in human hepatocellular carcinoma.Hepatology,2000,31,1080~5
  • 7Takai N,Miyazaki T,Nishida M,et al.Survivin expression correlates with clinical stage,histological grade,invasive behavior and survival rate in endometrial carcinoma.Cancer Lett,2002,184,105~16
  • 8Tanaka K,Iwamoto S,Gon G,et al.Expression of survivin and its relationship to loss of apoptosis in breast carcinoma.Clin Cancer Res,2000,6,127~34
  • 9Gazzaniga P,Gradilone A,Giuliani L,et al.Expression and prognostic significance of livin,survivin and other apoptosis-related genes in the progression of superficial bladder cancer.Ann Oncol,2003,14(1),85~90
  • 10Mirza A,McGuirk M,Hockenberry TN,et al.Human survivin is negatively regulated by wild-type p53 and participate in p53-dependent apoptotic pathway.Oncogene,2002,21,2613~22

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