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胰岛素样激素3的研究进展 被引量：5

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摘要 胰岛素样激素 3(INSL3)又称松弛素样因子 (RLF)或睾丸间质细胞源胰岛素样肽 (LEY IL) ,是oGPCRsLGR8的内源性配体 ,是人类睾丸间质细胞分化成熟的标记。在睾丸间质瘤及人类乳房上皮细胞中存在INSL 3的表达。INSL3在血浆中浓度较高 。
作者 张宝红 杜军保 唐朝枢
机构地区 北京大学第一医院心血管研究所 北京大学第一医院儿科研究室
出处 《国外医学（生理病理科学与临床分册）》 2004年第2期114-115,共2页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家自然科学基金重点项目(G2 0 0 0 0 5 690 5 3 9870 844 )
关键词 胰岛素样激素3(INSL3) 孤儿G蛋白偶联受体 配体
分类号 R341 [医药卫生—基础医学]
  • 相关文献

参考文献10

  • 1Howard AD,McAlister G,Soctt DF,et al.Orphan G-rpotein-coupled receptors and natural ligand discovery [ J ] .Trends Pharmacol Sci,2001,22:132-140.
  • 2Shclagh W,Derk JB,Jon KC,et al.Orphan G-protein-coupled receptors: the next generation of drug targets [ J ].British J Pharm,1998,125:1387-1392.
  • 3Kumagai J,Hsu SY,Matsumi H,et al.INSL3/Leydig insulin-like peptide activates the LGR8 recetptor important in testis desctent [J].J Biol Chem,2002,277(35):31283-31286.
  • 4Claasz AA,Bond CP,Bathgate RA,et al.Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues [ J ].Eur J Biochem,2002,269(24):6287-6293.
  • 5Bullesbach EE,Schwabe C.Tryptopan B27 in the relaxin-like factor(RLF) is crucialfor RLF receptor-binding [ J ].Biochemistry,1999,38(10):3073-3078.
  • 6Burkhard E,Adham IM,Brosig B,et al.Structural organization of the porcine and human genes coding for a Leydig cdll-specific insulin-like peptide(LEY I-L) and chromosomal localizaion of the human gene (INSL3) [ J ].Genomics,1994,20 (1): 13-19.
  • 7Kubota Y,Net S,Farmer PJ,et al.Leydig insulin-like hormone,gubernacular development and testicular descent [ J ].J Urol,2001,165(5): 1673-1675.
  • 8Tomboc M,Lee PA,Mitwally MF,et al.Insulin-like 3/relaxin-like factor gene mutations are associated with cryptorchidism [ J ].J Clin Endocrinol Metab,2000,85 (11):4013-4018.
  • 9Hombach-Klonisch S,Hoang-Vu C,Kehlen A,et al.INSL-3 is expressed in human hyperplastic and meoplastic thyrocytes [ J ].Int J Oncol,2003,22 (5):993-1001.
  • 10Samuel CS,Parry LJ,Summers RJ.Physiological or pathological-a role for relax in the cardiovascular[J].Current Opinion in Pharmacolohy ,2003,3:152-158.

同被引文献76

  • 1Xue-WuJiang,Jian-HongLi,Tian-HuaHuang,Wang-DongDeng.Effect of prenatal exposure to diethylstilbestrol on gubernacular development in fetal male mice[J].Asian Journal of Andrology,2004,6(4):325-329. 被引量：14
  • 2邱志群,舒为群,曹佳.我国水中有机物及部分持久性有机物污染现状[J].癌变．畸变．突变,2007,19(3):188-193. 被引量：32
  • 3常兵,刘德瑜,梁玉香,吴燕婉.邻苯二甲酸二丁酯对青春期雄性大鼠的生殖毒性研究[J].中国自然医学杂志,2007,9(3):164-168. 被引量：12
  • 4Shu Feng, Victoria K. Cortessis, Andrew Hwang, et al. Mutation analysis of INSL- 3 and GREAT/LGR8 genes in familial cryptorchidism. Urology, 2004,64(5) :1032 - 1036.
  • 5Alberto Ferlin, Mauro Simonato, Lucia Bartoloni, et al. The INSL3 LGR8/GREAT ligand - receptor pair in human cryptorchidism. The Journal of Clinical Endocrinology & Metabolism, 2003,88 ( 9 ) : 4273- 4279.
  • 6Kumagai J, Hsu SY, Matsumi H, et al. INSL 3/Leyding insulin -like peptide activates the LGR8 recetptor important in testis descent.J Biol Chem, 2002,277(35) :31283 -31286.
  • 7Claasz AA, Bond CP, Bathgate RA, et al. Relaxin -like bioactivity of ovine Insulin 3 ( INSL - 3) analogues. Eur J Bioche M ,2002,269(24) :6287 - 6293.
  • 8Antonia A. Claasz, Courtney P. Bond, Ross A. Bathgate, et al. Relaxin - like bioaetivity of ovine Insulin 3 ( INSL3 ) analogues. European Journal of Biochemistry. 2002,269(24) :6287.
  • 9Bullesbach EE, Schwabe C. Tryptopan B27 in the relaxin - like factor(RLF) is crucial for RLF receptor binding. Bichemistry, 1999,38(10) :3073 -3078.
  • 10Anne Truong, Natalia V. Bogatchcva, Claude Schelling, et al. Isolation and expression analysis of the canine insulin like factor -3 gene.Biology of reproduction,2003,69:1658 - 1664.

引证文献5

二级引证文献11

国外医学（生理病理科学与临床分册）
2004年 第2期

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