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糖基化磷脂酰肌醇特异性磷脂酶D基因表达与临床相关疾病 被引量：1

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摘要 羧基端结合有糖基化磷脂酰肌醇 (GPI)结构的膜蛋白称为GPI锚定蛋白 ,具有广泛功能。糖基化磷脂酰肌醇特异性磷脂酶D(GPI PLD)是人体内唯一能特异性水解GPI并能释放出锚定蛋白的磷脂酶 ,可调节锚定蛋白的表达和生理功能。GPI PLD可能成为评估预后的标记物。在某些肝脏疾病、恶性肿瘤、糖尿病等疾病中有GPI
作者 卢岳 陈方平
机构地区 中南大学湘雅医院血液内科
出处 《国外医学（生理病理科学与临床分册）》 2004年第2期138-141,共4页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 糖基化磷脂酰肌醇 锚定蛋白 磷脂酶D 相关疾病
分类号 R365 [医药卫生—病理学]
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参考文献18

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同被引文献11

  • 1王依丹,唐建华,杨智英,禹虹,向新颖.GPI-PLD基因表达在K562细胞对补体杀伤的敏感性中的影响[J].中南大学学报（医学版）,2004,29(6):654-657. 被引量：2
  • 2唐建华,谭超超,李桂源.糖基化磷脂酰肌醇锚定蛋白质与肿瘤[J].中南大学学报（医学版）,2005,30(5):612-615. 被引量：4
  • 3苏立新,张陈平.肿瘤失巢凋亡的研究进展[J].国际口腔医学杂志,2006,33(5):387-389. 被引量：4
  • 4Mann K J, Hepworth M R, Raikwar N S, et al. Effect of glycosylphosphatidylinositol (GP1)-phospholipase D overexpression on GP1 metabolism [ J ] . Biochem J, 2004,378 (Pt2) : 641 -648.
  • 5Raymond F D, Fortunato G, Moss D W, et al. Inositolspecific phospholipase D activity in health and disease [ J ]. Clin Sci(Lond) , 1994,86(4) : 447-451.
  • 6Naqhibalhossaini F, Yoder A D, obi M, et al. Evolution of tumorgenie property conferred by glyeophophatidylinosiflol membrane anchors of earcinoembryonie antigen gene family members during the primate radiation [ J ] . Mol Biol Cell, 2007, 18(4): 1366-1374.
  • 7Ordonez C, Zhai A B, Camacho-Leal P, et al. GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological deflects through enhanced integrin alpha5betal-fibronectin interaction [ J ]. J Cell Physio, 2007,210(3) : 757-765.
  • 8Chan C H, Cook D, Stanners C P. Increased colon tumor susceptibility in azoxymethane treated CEABAC transgenic mice[J]. Carcinogenesis, 2006,27(9) : 1909-1916.
  • 9唐建华,李文凯.血清糖基化磷脂酰肌醇特异性磷脂酶D的检测[J].湖南医科大学学报,1999,24(2):119-122. 被引量：17
  • 10钱莉玲,常立文.小窝及小窝蛋白的研究进展[J].国外医学（分子生物学分册）,2002,24(2):100-102. 被引量：10

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国外医学（生理病理科学与临床分册）
2004年 第2期

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