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NOD2基因3020insC移码突变与中国湖北汉族炎症性肠病的相关性 被引量：2

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摘要 目的:研究我国湖北汉族人NOD2基因3020insC移码突变频率与炎症性肠病(IBD)的相关性. 方法:采用特异性等位基因PCR方法对74例溃疡性结肠炎(UC)、15例克罗恩病(CD)患者以及172例正常对照者NOD2基因3020insC多态性进行检测. 结果:正常对照者、UC以及CD患者NOD2基因3020等位基因频率分别为0.29%,1.35%及3.33%,均无显著性差异.但CD对比健康对照组的P=11.828,95%CI=0.7 205- 194.17,提示NOD2基因3020insC移码突变是CD的危险因素. 结论:NOD2基因3020insC移码突变与中国湖北汉族CD与UC患者无显著相关性.
作者 瞿艳 郭秋莎 夏冰
机构地区 武汉大学中南医院综合医疗科
出处 《世界华人消化杂志》 CAS 2004年第5期1208-1210,共3页 World Chinese Journal of Digestology
基金 国家自然科学基金资助课题 No.30370638
关键词 NOD2基因 3020insC移码突变 中国 湖北 汉族 炎症性肠病 IBD 遗传因素
分类号 R574.4 [医药卫生—消化系统]
  • 相关文献

参考文献11

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二级参考文献10

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共引文献1126

同被引文献11

  • 1郑家驹.NOD2基因突变与克罗恩病易感性及临床表型的关系[J].中华消化杂志,2004,24(7):443-444. 被引量：2
  • 2高敏,曹倩,罗灵和,吴敏良,胡伟玲,姒健敏.NOD2/CARD15基因多态性与克罗恩病患者相关性研究[J].中华内科杂志,2005,44(3):210-212. 被引量：22
  • 3Maria Gazouli,Gerassimos Mantzaris,Athanassios J Archimandritis,George Nasioulas,Nicholas P Anagnou.Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease[J].World Journal of Gastroenterology,2005,11(47):7525-7530. 被引量：12
  • 4张以洋,智发朝,周殿元,姜泊,赖卓胜,张迎春,钟长青,龙靖华,徐迪辉,张奕.克罗恩病CARD15/NOD2基因突变的研究[J].中华消化杂志,2006,26(7):456-459. 被引量：15
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引证文献2

二级引证文献4

世界华人消化杂志
2004年 第5期

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