期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

NOD2基因3020insC移码突变与中国湖北汉族炎症性肠病的相关性 被引量：2

下载PDF
导出
摘要 目的:研究我国湖北汉族人NOD2基因3020insC移码突变频率与炎症性肠病(IBD)的相关性. 方法:采用特异性等位基因PCR方法对74例溃疡性结肠炎(UC)、15例克罗恩病(CD)患者以及172例正常对照者NOD2基因3020insC多态性进行检测. 结果:正常对照者、UC以及CD患者NOD2基因3020等位基因频率分别为0.29%,1.35%及3.33%,均无显著性差异.但CD对比健康对照组的P=11.828,95%CI=0.7 205- 194.17,提示NOD2基因3020insC移码突变是CD的危险因素. 结论:NOD2基因3020insC移码突变与中国湖北汉族CD与UC患者无显著相关性.
作者 瞿艳 郭秋莎 夏冰
机构地区 武汉大学中南医院综合医疗科
出处 《世界华人消化杂志》 CAS 2004年第5期1208-1210,共3页 World Chinese Journal of Digestology
基金 国家自然科学基金资助课题 No.30370638
关键词 NOD2基因 3020insC移码突变 中国 湖北 汉族 炎症性肠病 IBD 遗传因素
分类号 R574.4 [医药卫生—消化系统]
  • 相关文献

参考文献11

  • 1Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP,Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-puig P, GowerRousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G.Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
  • 2Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP,Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G,Cho JH. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-606.
  • 3Yamazaki K,Takazoe M, Tanaka T, Kazumori T, Nakamura Y. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet 2002;47:469-472.
  • 4Leong RW, Armuzzi A, Ahmad T, Wong ML, Tse P, Jewell DP, Sung JJ. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther 2003;17:1465-1470.
  • 5Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G.Nod2, a Nodl/Apaf-1 family member that is restricted to monocytes and activates NF-kB. J Biol Chem 2001;276:4812-4818.
  • 6欧阳钦,潘国宗,温忠慧,万学红,胡仁伟,林三仁,胡品津.对炎症性肠病诊断治疗规范的建议[J].中华消化杂志,2001,21(4):236-239. 被引量：1122
  • 7Hugot JP, Laurent-puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL, Van Gossum A, Groupe d'Etude Therapeutique des Affections Inflammatolres Digestives, Orholm M, Bonaiti-pellie C, Weissenbach J,Mathew CG, Lennard-Jones JE, Cortot A, Colombel JF, Thomas G. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996:379:821-823.
  • 8夏冰,邓长生,Pena AS.克罗恩病的第一个易感基因,NOD2(CARD15)[J].中华消化杂志,2002,22(5):307-308. 被引量：6
  • 9Berrebi D, Maudinas R, Hugot JP, Chamaillard M, Chareyre F, De Lagausie P, Yang C, Desreumaux P, Giovannini M,Cezard JP, Zouali H, Emilie D, Peuchmaur M. Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon. Gut 2003;52:840-846.
  • 10Lala S, Ogura Y, Osborne C, Hor SY, Bromfield A, Davies S,Ogunbiyi O, Nunez G, Keshav S. Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 2003;125:47-57.

二级参考文献10

  • 1Inohara N,Ogura Y,Chen FF,et al.Human Nod1 confers responsiveness to bacterial lipopolysaccharides[].Journal of Biological Chemistry.2001
  • 2Hampe J,Cuthbert A,Croucher PJ,et al.Association between insertion mutation in NOD2 gene and Crohn’s disease in German and British populations[].The Lancet.2001
  • 3Inohara N,Koseki T,Lin J,et al.An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways[].Journal of Biological Chemistry.2000
  • 4Satsangi J.Genetics of inflammatory bowel disease: from bench to bedside[].Acta Odontologica Scandinavica.2001
  • 5Inohara N,Nunez G.The NOD: a signaling module that regulates apoptosis and host defense against pathogens[].Oncegene.2001
  • 6Ogura Y,Inohara N,Benito A,et al.Nod 2, a Nod 1/Apaf-1 family member that is restricted to monocytes and activates NF-kappa B[].Journal of Biological Chemistry.2001
  • 7Hugot JP,Laurent-Puig P,Gower-Rousseau C,et al.Mapping of a susceptibility locus for Crohn’s disease on chromosome 16[].Nature.1996
  • 8Cavanaugh J.International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16[].The American Journal of Human Genetics.2001
  • 9Ahmad T,Satsangi J,Mcgovern D,et al.Review article: the genetics of inflammatory bowel disease[].Alimentary Pharmacology and Therapeutics.2001
  • 10Ogura Y,Bonen DK,Inohara N,et al.A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease[].Nature.2001

共引文献1125

同被引文献11

  • 1郑家驹.NOD2基因突变与克罗恩病易感性及临床表型的关系[J].中华消化杂志,2004,24(7):443-444. 被引量：2
  • 2高敏,曹倩,罗灵和,吴敏良,胡伟玲,姒健敏.NOD2/CARD15基因多态性与克罗恩病患者相关性研究[J].中华内科杂志,2005,44(3):210-212. 被引量：22
  • 3Maria Gazouli,Gerassimos Mantzaris,Athanassios J Archimandritis,George Nasioulas,Nicholas P Anagnou.Single nucleotide polymorphisms of OCTN1, OCTN2, and DLG5 genes in Greek patients with Crohn's disease[J].World Journal of Gastroenterology,2005,11(47):7525-7530. 被引量：12
  • 4张以洋,智发朝,周殿元,姜泊,赖卓胜,张迎春,钟长青,龙靖华,徐迪辉,张奕.克罗恩病CARD15/NOD2基因突变的研究[J].中华消化杂志,2006,26(7):456-459. 被引量：15
  • 5Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature, 2001, 411:599-603.
  • 6Girardin SE, Boneca IG, Viala J, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem, 2003, 278:8869-8872.
  • 7Voss E, Wehkamp J, Wehkamp K, et al. NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem, 2006, 281:2005-2011.
  • 8Yamazaki K, Takazoe M, Tanaka T, et al. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet, 2002, 47:469-472.
  • 9Croucher PJ, Mascheretti S, Hampe J, et al. Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations. Eur J Hum Genet, 2003, 11:6-16.
  • 10Leong RW, Armuzzi A, Ahmad T, et al. NOD2/CARD15 gene polymorphisms and Crohn's disease in the Chinese population. Aliment Pharmacol Ther, 2003, 17:1465-1470.

引证文献2

二级引证文献4

世界华人消化杂志
2004年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部