纳洛酮治疗新生儿缺氧缺血性脑病的临床观察

Treatment of neonatal hypoxic ischemic encephalopathy with naloxone

目的 :观察纳洛酮治疗中、重度新生儿缺氧缺血性脑病 (HIE)的疗效。方法 :在常规治疗的基础上 ,对 32例加用纳洛酮 ,并与对照组 2 0例比较。结果 :两组临床症状和体征恢复时间差异均有显著性 (P <0 .0 5～P <0 .0 1 )。结论 :纳洛酮治疗中。

Objective:To observe the clinical effect of naloxone in the treatments of neonatal hypoxic ischemic encephalopathy(HIE).Methods:Combination therapy of naloxone and routine treatment was applied to 32 newborn with HIE and 20 other newborn with HIE receiving only routine treatment as control.Results:The time for disappearance of clinical symptoms and recovery was shorter in the treatment group than in the control group( P <0.05 to P <0.01).Conclusions:The therapeutic effect of naloxone in the treatment of HIE is apparently better than that of routine therapy.