糖皮质激素受体与虚证的关系及中药的调节

Relationship between glucocorticoid receptor and deficiency-syndrome and the regulation of traditional Chinese medicine

糖皮质激素受体 (glucocorticoidreceptor,GR)属细胞内核受体超家族中的一员 ,是一种配基依赖型转录因子。GR几乎在机体的所有有核细胞中表达 ,在很多生理以及病理过程中发挥重要作用 ,包括维持内环境的稳定、抗应激、调节神经系统的功能等。另外 ,糖皮质激素的抗炎、抗自身免疫和抗肿瘤的作用也是由GR介导的 ,因此 ,GR也是重要的免疫系统调节因子。通过调节GR ,可以对机体和细胞的生理、病理状态产生重要影响。中医药在调节糖皮质激素受体方面也进行了许多探索 ,为中医药作用机制研究奠定了现代生理病理学基础。

The glucocorticoid receptor (GR) is a ligand-dependent transcription factor belonging to the nuclear hormone receptor superfamily. Due to its almost ubiquitous expression, GR plays an important role in many physiological and pathological processes. These include regulation of homeostasis, adaptation to stress, and modulation of central nervous system. In addition, GR is a major modulator of the immune system due to its proficient anti-inflammatory and immunosuppressive activity; and its function is important for proper regulation of many physiological processes. The exploration on the regulation of traditional Chinese medicine on GR has established a modern physiological and pathological foundation for research of traditional Chinese medicine.