盐酸丁咯地尔治疗2型糖尿病疗效观察

The effect of buflomedil on type 2 diabetes mellitus

目的 观察盐酸丁咯地尔对糖尿病患者血粘度、红细胞变形能力、血小板聚集功能、血糖及胰岛素敏感性的影响。方法 6 4例 2型糖尿病患者在保持原有饮食、运动、药物不变基础上随机分为两组 ,治疗组给予盐酸丁咯地尔 2 0 0 mg/d,静脉滴注 14天 ,对照组给予维生素 C、维生素 B6 静脉点滴。结果 应用盐酸丁咯地尔治疗后全血粘度、红细胞变形能力、血小板聚集功能、血糖、 Hom a- IR指数均明显改善 (P <0 .0 5～ 0 .0 1)。结论 盐酸丁咯地尔能显著改善 2型糖尿病患者血粘度、红细胞变形能力、血小板聚集功能 ,能增加胰岛素敏感性 ,有显著的协助降糖作用 ,并可能影响糖尿病患者的亚临床炎症状态。

Objective To study the effect of buflomedil on blood viscosity RBC deformability and the senstivity of insulin in type 2 diabetes mellitus. Methods 64 cases of type 2 diabetes mellitus patients were divided into two groups based on the previous treatment of diabetes mellitus,the buflomedil treatment group were given buflomedil 200mg intravenously everyday for 14 days;the control group were treated with vitamine C and vitamine B 6.Results After treated with buflomedil, there were significantly difference in blood viscosity RBC deformability platelet aggregation and the senstivity of insulin(P<0.05～0.01). Conclusion Buflomedil can significantly improve blood viscosity, RBC deformability,platelet aggregation and the senstivity of insulin in patients with type 2 diabetes mellitus.It can also improve glucose and influence chronic inflammation state.