VEGF表达及其与非小细胞肺癌转移、预后关系的研究

Exprssion of vacular endothelial growth factor in NSCLC and its correlation with metastases and prognosis

目的 探讨血管内皮生长因子 (VEGF)在非小细胞肺癌 (NSCL C)组织中的表达及其与转移、预后的关系。方法 应用免疫组织化学 (S- P)法检测 96例肺癌组织、 31例癌旁组织及 2 0例肺良性瘤样组织的VEGF表达水平 ,并对其与临床、病理特征的关系进行分析。结果 肺癌、癌旁及肺良性瘤样病变组织中 VEGF阳性表达率分别为 72 .9%、 4 5 .2 %和 2 5 % ,三者之间具有显著性差异 (P <0 .0 5 ) ;VEGF在肺癌组织中的表达与患者的年龄、性别、吸烟、临床分期、分化程度、肿瘤直径及血行转移无关 ,与肺癌的组织学类型、淋巴结转移有关 ;VEGF表达阳性患者生存时间明显短于阴性患者 ,VEGF的表达与生存时间呈负相关。结论 不同性质的肺病变组织中 VEGF表达不同 ,可以作为 NSCL C临床诊断的可靠指标 ;VEGF和 NSCL C的转移、预后有关 。

Objective To study the expression of VEGF and its correlation with metastasis and prognosis in NSCLC.Methods Expression of VEGF was detected by Streptavidin-Peroxidase(SP)method in 96 cases of NSCLC,31 adjacent tumor tissues and 20 benign lesions respectively,the relationship between such expression and clinicopathological features of NSCLC was also studied.Results VEGF was expressed in 70 of 96(72.9%) cases of lung cancer,14 of 31(45.2%) cases of adjacent tumor tissues and 5 of 20(25%) of benign lesions;there was no significant difference between VEGF expression and age,sex,cigarette smoking,histologic subtype and differentiation,there was correlation about lymph node metastasis,TNM stages and prognosis of patients.Conclusion VEGF was overexpressed in NSCLC and may serve as definite diagnostic marker.There was relationship between its expression and metastasis and prognosis,It is an effective prognostic factor for NSCLC.