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AIDS病人外周血T淋巴细胞亚群和IL-6、IL-8水平的变化 被引量：1

CHANGES OF T LYMPHOCYTE SUBSETS AND INTERLEUKIN-6 AND INTERLEUKIN-8 LEVELS IN THE PERIPHERAL BLOOD OF AIDS PATIENTS
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摘要 ①目的　探讨获得性免疫缺陷综合征 (AIDS)病人外周血T淋巴细胞亚群和白细胞介素 6 (IL 6 )、白细胞介素 8(IL 8)水平的变化。②方法　采用碱性磷酸酶抗碱性磷酸酶 (APAAP)法和夹心酶联免疫吸附法检测 4例AIDS病人和 2 0例健康人T淋巴细胞亚群和IL 6、IL 8水平的变化。③结果　AIDS病人CD2、CD4、CD4 /CD8明显降低 ,而CD8和IL 6、IL 8则明显增高 ,与对照组比较差异均有极显著性 (t或t′=4 .37～ 17.19,P <0 .0 0 1)。④结论　T淋巴细胞亚群和IL 6、IL Objective To explore the changes of T lymphocyte subsets and interleukin-6(IL-6) and IL-8 levels in AIDS patients. Methods The T lymphocyte subsets and IL-6 and IL-8 were measured in four AIDS patients and 20 normal controls by using alkaline phosphatase anti-alkaline phosphatase (APAAP) assay and sandwich enzyme linked immunosorbent assay (ELISA). Results CD2, CD4, and CD4/CD8 were lower, while CD8 and IL-6 and IL-8 were higher in AIDS patients than those in the controls (t or t′=4.37-17.19, P<0.001). Conclusion The detection of T lymphocyte subsets and IL-6 and IL-8 may be served to observe AIDS patients and monitor their responses to treatment.
作者 荆永正 高杰 孙凤英 迟文平
机构地区 蓬莱市人民医院基因室
出处 《齐鲁医学杂志》 2004年第2期153-153,155,共2页 Medical Journal of Qilu
关键词 AIDS 外周血 T淋巴细胞亚群 IL-6 IL-8 acquired immunodeficiency syndrome T-lymphocyte subsets interleukin-6 interleukin-8
分类号 R512.91 [医药卫生—内科学]
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参考文献2

  • 1Rosati M, Valentin A,Patenaude DT, et al. CCAAT-Enhancer-binding protein beta(C/EBPbeta)actirates CCR5 promo-ter: increased C/EBP beta and CCR5 in T lymphocytes from HIV-1-infected individuals[J]. Immunol, 2001, 167(3):1654.
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同被引文献12

  • 1江振友,高阳,方丹云,周经姣,晏辉钧,江丽芳.SARS患者血清IL-8、IL-12和TGF-β1的检测及意义[J].中国免疫学杂志,2004,20(10):717-719. 被引量：6
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  • 5Harada A ,Sekido N , Kuno K,et al. Expression of recombinant rabbit IL-8 in E. Coli and establishement of the essential invilvement of IL-8 in reruiting neutrophils into liopolysaccharid-induced inflammatory site of rabbit skin[J]. Internal Immunol,1993,5∶681.
  • 6Matsushima K, Baldwin ET, Mukaida N. Interleukin-8 and MCAF: Novel leukocyte recruitment and activation cytokines[J]. Chem Immunol,1992,51∶236.
  • 7Terui Y, lkeda M, tomizuka H, et al. Activated endothelial cells induce apoptosis in leukemic cells by endothelial interleukin-8[J]. Blood,92(8)∶2672.
  • 8Pruijt JFM, Fibbe WE, Laterveer L, et al. Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B(MMP-9)[J]. Proc Natl Acad Sci USA,1999,96∶10863.
  • 9张毅,朱剑昆,张雁云,刘继明,邱玉华,李新燕,刘蓓岭,谢炜,郑列琳,冯丽瑾,郭玲,朱学东,强亦忠,张学光.小鼠静脉内注射白细胞介素8对动员骨髓造血干/祖细胞的作用研究[J].中华血液学杂志,1998,19(12):642-645. 被引量：3
  • 10刘继明,张学光,施勤,张毅,朱华亭,徐影,张维延,强亦忠.大肠杆菌表达重组人IL-8分离纯化工艺的建立[J].苏州医学院学报,2000,20(4):340-343. 被引量：4

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齐鲁医学杂志
2004年 第2期

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