儿童性腺外卵黄囊瘤(附21例报告)

Extragonadal Yolk Sac Tumour in children(Report of 21 Cases).

本文报告21例性腺外卵黄囊瘤,发生于骶尾部13例,其中4例混存畸胎瘤,腹膜后3例,腹腔内、阴道、纵隔、椎管内及颅内各1例。11例术前作血清甲胎蛋白明显升高.作者认为对于身体中线附近的肿瘤,包括从骶尾部直至颅内,凡生长迅速、转移早、X 线照片无钙化者,均应将卵黄囊瘤考虑在鉴别诊断之中。对于具有明显骨化和钙化影的肿瘤亦不能完全视为单一的畸胎瘤,而应警惕混存卵黄囊瘤的可能性。血清甲胎蛋白的测定对术前诊断和术后复发监测都有重要临床意义。

21 cases of extragonadal yolk sactumour in children were reported.In13 patients the primary tumour occur-red in sacrococcygeal region including4 cases combined with teratoma,where-as 3 cases in retroperitoneal space andone each in intraperitoneal cavity,ya-gina,mediastinum,spinal,canal,in-tracranial area respectively.The serumalpha fetoprotein was increased mar-kedly in 11 cases examined preoperati-vely.We suggest that the yolk sac tu-mour should be included in differentialdiagnosis while the tumour is locatednearby the midline of the body,growsrapidly,metastasizes early and con-tains no calcification,the possibilityof combination of yolk sac tumour wi-th teratoma remains to be alerted evenif the calcification or ossification ty-pical of teratoma is apparent.Deter-mination of serum alpha fetoproteinis of great importance in preoprativediagnosis and postoperative monitoringof recurrence.