膳食低钙在克山病心肌坏死发生中的作用——Ⅱ.病区粮偏食实验及补钙的保护作用

EFFECT OF LOW CALCIUM IN DIET ON PATHOGENESIS OF MYOCARDIAL NECROSIS IN KESHAN DISEASE——Ⅱ.EXPERIMENTS OF MONOTONOUS DIET FROM A KESHAN DISEASE AREA AND PROTECTIVE EFFECTS OF CALCIUM SUPPLEMENTATION

以玉米面为主组成单一的病区粮偏食,低硒低钙特别突出,再短暂降低血钙情况下,缺氧因素引起急剧心肌坏死,类似克山病的心肌坏死。补充钙明显改善动物生长状态并减轻心肌坏死程度,结合病区易感人群膳食低钙,进一步提示膳食低钙在心肌坏死中有重要作用。并说明克山病的发生不仅有环境地球化学因素,还有膳食组成上的因素。

Monotonous diet mainly consisting of corn cultivated in the endemic area of Keshan disease was prominently lower in selenium and calcium. An acute and severe myocardial necrosis was induced by anoxic factor in the rats kept on the diet and made transient decrease of calcium in blood. The pattern of necrosis was similar to that of the myocardial necrosis of keshan disease. The growth state of the rats was significantly improved and the extent of myocardial necrosis was reduced when the monotonous diet was supplemented with calcium alone. In consideration of the fact that the diet of susceptible population in Keshan disease areas was low in calcium,it is further suggested that low calcium in diet may play an important role in the pathogenesis of myocardial necrosis of Keshan disease. It is also suggested that not only the environmeutal geochemical factor, but also the diet component is responsible for the occurrence of Keshan disease.