聚乳酸的合成研究

STUDY OF THE SYNTHESIS OF POLY(LACTIC ACID)

聚乳酸是一种具有良好生物相容性、可降解的高分子材料,被广泛应用于医用领域,受到越来越多的关注。聚乳酸的合成主要有两种方法:乳酸直接缩聚和丙交酯的开环聚合。文中综述了近年来聚乳酸合成研究的最新进展,讨论了直接合成时的反应条件对聚乳酸分子量的影响,以及不同催化剂对丙交酯开环聚合的影响,介绍了聚乳酸聚合的一种高效方法——反应挤出法,并展望了聚乳酸合成研究的前景。

Poly(lactic acid) (polylactide, PLA) is a biocompatible and bioresorbable polymer, thus it is widely used in the medical area, and is paid much attention to. There are two main methods to synthesis PLA, condensation polymerization of lactic acid and ring-opening polymerization of lactide. In the paper, the process of the new research of the synthesis PLA was reviewed, and the effect of reaction condition on the PLA molecular weight and the effect of different catalyst on ring opening polymerization of lactide were discussed. Beside, the PLA synthesis method of reactive extrusion was introduced, which is a high efficiency method. Finally, the foreground of PLA synthesis was prospected.