淀粉样脑血管病的病理

Pathological study on cerebral amyloid angiopathy.

26例淀粉样脑血管病(CAA)中,脑出血20例,蛛网膜下腔出血2例,脑梗塞3例,硬膜下血肿1例。CAA主要累及脑实质的小、中动脉的中膜及外膜以及毛细血管。本组50％病例有淀粉样脑血管病伴随血管病(CAA-AV),包括微小动脉瘤、“双桶”、葱皮样改变、类纤维素性坏死、微小动脉丛及血管周围淋巴细胞浸润。CAA往往同时伴有老年斑和神经原纤维缠结。

The cerebral amyloid angiopathy (CAA) was pathologically confirmed in 26 cases which included 20 cerebral hemorrhage,2 subarachnoid hemorrhage,3 cerebral infarction,and 1 subdural hema-toma.The CAA was mainly involved inthe media and extima of small and me-diumsized arteries as well as capillaries of the brain tissue.A half of all cases in the present paper had associated vas-culoangiopathies (CAA-AV),including microaneurysms,double barreling,onion skin-like intima,fibrinoid necrosis,clusters of arterioles and perivacular lympho-cytic infiltrations.The CAA was often accompanied with the senile plaques and neurofibrillary tangles.