以糖和穿心莲内酯为原料合成1,2-和1,3-二醇环磷酸酯

Synthesis of 1,2- and 1,3-diolcyclophosphate by Using Sugar and Andrographolide

以1,2-丙叉基木糖、1,2-丙叉基葡萄糖、穿心莲内酯、脱水穿心莲内酯为原料和磷酰氯作用,通过一锅法以较 高的产率分别得到了六元和五元环磷酸酯,并对反应条件进行了优化.所合成的化合物结构经13C-NMR、 H-NMR、13P-NMR、MS和元素分析确证.

Some cyclophosphate derivatives are synthesized by using 1, 2-di-O-isopropylglucose, 1, 2-di-O-isopropylxylose, andrographolide and 11, 12-dehydroandrographolide as starting materials in the presence of POCI3. The conditions and the possible mechanism of the reaction are discussed. The structures for all compounds are elucidated by 13C-NMR,1H-NMR ,31 P-NMR and MS.