NF-κB和IκB在膀胱癌中的表达及意义

Expression and Significance of NF-κB and IκB in Bladder Transitional Cell Carcinoma

膀胱移行细胞癌石蜡包埋标本54例,正常对照标本13例。采用免疫组化SP法研究NF κB和IκB的表达,分析NF κB与膀胱癌分级、分期、复发及转移的关系,以及NF κB和IκB的关系。结果表明,NF κBP65和IκBα在54例膀胱癌中的阳性表达率分别为88.9%、87.0%。NF κB阳性表达率随膀胱移行细胞癌分级、分期的增高有降低趋势,而随复发及转移的增多而增高。因此推论NF κB可能在膀胱癌早期起促进作用,且有望作为评价膀胱癌恶性度、肿瘤进展的指标。NF κB与IκB在膀胱癌中的表达具有正相关性。

The expression of NF-κB and IκB in 54 paraffin-embeded and 13 controled samples was examined by SP immunohistochemistry. The expression of NF-κB in bladder transitional cell carcinoma was studied in order to find its relationship with the grade ,the stage, the recurrence and the metastasis of bladder transitional cell carcinoma. It is demonstrated that the positive expression rate of NF-κBP65 in bladder transitional cell carcinoma was 88.9%,IκBα was 87.0%. The high expression rate of NF-κB was associated with low grade and staging,and withhigh recurrence rate and metastasis rate. It is deduced that NF-κB probably accelerate the progression of bladder transitional cell carcinoma in early stage and accelerate the recurrence and metastasis.It probably serves as a parameter to judge malignancy and progression.There is a positive correlation between NF-κB and IκB.