肝细胞产生胶原纤维的进一步研究

Further Studies of Collagen Biosynthesis by Hepatocytes

对32例肝胆系统疾病的肝穿刺材料进行电镜观察,发现肝内增生的胶原纤维不仅存在于汇管区及Disse腔,也见于肝细胞内。肝细胞内的胶原绝大部分为胶原原纤维,其排列紊乱,混杂于肝细胞器之间,无界膜包裹,提示肝细胞内的胶原原纤维由肝细胞所产生。

Electron microscopic observation, was carried out on 32 biopsies from liver and biliary system diseases. It was found that proliferative collagen in the liver was located not only in the portal space and Disse space, but also in the hepatocytes. Most of the collagen seen in hepatocytes were in the form of collagen fibrils, oriented irregularly, intermingled with the organelles and without a delimiting membrane. Therefore, the authors suggest that these collagen fibrils were produced by the hepatocytes themselves.