肝病患者347例血清总胆汁酸检测及其临床意义探讨

DETECTION OF SERUM TOTAL BILE ACID AND ITS CLINICAL SIGNIFICANCE FOR LIVER DISEASES

目的 :探讨肝病患者血清总胆汁酸检测及其临床意义。方法 :用酶比色法检测 347例肝病患者的血清总胆汁酸浓度。结果 :急性肝炎、慢性乙肝中度、慢性乙肝重度、肝硬化、肝癌的TBA、ALT明显高于正常对照组 (P<0 0 1) ,慢性乙肝轻度与正常对照组对比差异无统计学意义 (P >0 0 5 )。各肝病间比较 ,肝硬化与肝癌差异无统计学意义 (P >0 0 5 ) ,慢性乙肝重度与肝硬化间差异有统计学意义 (P <0 0 5 ) ,其余各肝病间差异均有统计学意义(P <0 0 1)。结论 :胆汁酸水平是反映肝实质性损伤的一项灵敏指标。

Objective:To detect serum total bile acid level and investigate its clinical significance for liver diseases.Method:Enzyme colorimetry was used to detect concentration of serum total bile acid in 347 cases of liver diseases.Results:Serum total bile acid levels among the cases in acute hepatitis, moderate chronic hepatitis B, severe chronic hepatitis B,liver cirrhosis and hepatic carcinoma were remarkably higher than controlled group (P<0.01), but not in mild chronic hepatitis B (P>0.05). Comparison among the liver diseases showed that significant difference was not presented between cirrhosis and liver cancer (P>0.05); but presented between severe chronic hepatitis B and cirrhosis and among the other liver diseases (P<0.01).Conclusion:Bile acid is a sensitive index of reflecting liver damage.