姜黄对肝细胞色素P4501A2的影响

Effect of Rhizoma Curcumae longae on cytochrome P4501A2

目的 研究姜黄对肝细胞色素P4501A2的影响。方法 以咖啡因为工具药,HPLC法检测其药代动力学变化。结果 咖啡因因体内代谢减慢,半衰期延长。结论 姜黄可以抑制肝药酶,减慢咖啡因的代谢。

Objective To study the efiect of Rhizoma Curcumae longae on cytochrome P4501A2. Methodes Caffeine was used as control drug,and pharmacokinetics was studied by HPLC.Results The metabolism of caffeine was slowed,T1/2 of caffeine in the trial group was longer than that in the control group. Conclusions Rhizoma Curcumae longae inhibits the cytochrome P4501A2.