雷贝拉唑不同剂量和用法对健康人胃内昼夜pH变化的影响

Effect of different dosage and usage of rabeprazole on intragastric pH during daytime and nighttime

目的:观察雷贝拉唑不同剂量和用法对健康人昼夜胃内pH的影响。方法:10例健康志愿者接受4次24h胃内pH监测,即口服雷贝拉唑10mg 1次(A组)、10mg 2次(B组)、20mg 1次(C组)以及空白对照(D组),清洗期2周。结果:观察组(A,B,C)用药后胃内pH值较D组均显著增高(P<0.01);胃内pH>4的时间分别为(11.5±6.2)h,(12.9±6.5)h,(14.5±4.6)h(P>0.05)。C组白天胃内pH>4的时间百分比显著高于A和B组(P<0.05);而B组夜间pH值>4的时间百分比显著高于白天(P<0.05)。A,B,C组抑酸有效率分别为80%,80%和90%(P>0.05)。结论:雷贝拉唑的不同剂量和用法均能提高健康人胃内pH,不同剂量和用法有不同的抑酸特点,为临床合理选择剂量和用药方式提供了依据。

Objective: To investigate the effect of rabeprazole during daytime and nighttime with different dosage and usage on intragastric pH. Methods:10 healthy volunteers consisted of 6 males and 4 females with an average age of (23±1) were enrolled into the study. They were divided to re-ceive a single oral rabeprazole 10mg (Group A) ,a double oral rabeprazole 10mg (group B) ,a single oral rabeprazole 20mg (group C) or blank control (group D) and their pH value of gastric juice was moni-tored for 4 times within 24h. Results: After treatment, the pH value of gastric juice in groups A,B,and C were significantly increased compared with group D (P<0.01).The duration of time maintained at pH>after medication was (11.5±6.2)h for group A, (12.9±6.5)h for group B and (14.5±4.6) h for group C. The percentage of duration of time maintained at pH>4 at daytime for group C was significantly higher than that of group A or B (P<0.05). The corresponding data of group B at nighttime was significantly higher than that of daytime (P < 0.05). The effective rate for inhibition of acid was 80% for group A,80% for group B and 90% for group C. Conclusion:Rabeprazole with different dosage and usage significantly increased intragastric pH and showed different character of acid inhibition. The study provides evidence-based medicine for reasonable choice of dosage and usage clinically.