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PTEN在骨肉瘤组织中的表达及意义 被引量：2

Expression and significance of PTEN in osteosarcoma
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摘要 目的 :研究骨肉瘤组织中抑癌基因PTEN的表达情况 ,探讨其在骨肉瘤发生、发展中的可能作用。方法 :用免疫组化S P法检测PTEN蛋白在 38例骨肉瘤及 2 0例骨软骨瘤石蜡标本中的表达情况。结果 :PTEN蛋白在骨肉瘤中表达阳性率为 5 5 .3% ,在骨软骨瘤中为 90 .0 % ,骨肉瘤与骨软骨瘤相比有显著差异 (P <0 .0 1 )。结论 :抑癌基因PTEN蛋白在骨肉瘤组织中表达下调 。 Objective: To study the expression of a new tumor suppressor gene PTEN in carcinogenesis and development of osteosarcoma. Methods:Expression of PTEN was detected by using S P immunohistochemical method in 38 cases of paraffin embedded section of osteosarcoma and 20 cases of osteochondroma. Results:The positive rate of PTEN was 55.3 % in osteosarcoma and 90.0 % in osteochondroma. The difference was significant between osteosarcoma and osteochondroma(P<0.01) .Conclusion:The PTEN may play an important role in the carcinogenesis and development of osteosarcoma.
作者 黄涛 孙洁 吕刚 李建华 高大新 杨茂伟 王岩峰
机构地区 中国医科大学附属第一医院骨科 中国医科大学病理中心 沈阳医学院附属第二医院骨科
出处 《中国医科大学学报》 CAS CSCD 北大核心 2004年第3期245-246,共2页 Journal of China Medical University
关键词 骨肉瘤 PTEN蛋白 抑癌基因 osteosarcoma PTEN protein psotein tumor suppressor gene
分类号 R730.23 [医药卫生—肿瘤]
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参考文献12

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共引文献13

同被引文献24

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引证文献2

二级引证文献5

中国医科大学学报
2004年 第3期

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