摘要
目的 :研究肾癌组织中环氧化酶 2 (COX 2 )蛋白的表达 ,探讨COX 2表达与肾癌可能的相关性。方法 :应用免疫组织化学S P法 ,对 4 6例肾癌及其 2 5例癌旁组织COX 2蛋白表达进行检测。结果 :COX 2在 4 6例肾癌组织中的表达阳性百分比为 71 .74 % ,癌旁组织中为 32 .0 0 %。肾癌组织中COX 2表达与癌旁组织相比差异具有统计学意义 (P <0 .0 1 ) ;结论 :COX 2在肾癌组织中表达明显增高 ,与肾癌的发生、发展可能相关 。
Objective: To investigate the expression of cyclooxygenase 2(COX 2) in renal carcinoma. Methods: The S P method was used to determine the expression of COX 2 protein in 46 cases of renal carcinoma and 25 of normal tissue. Results: Positive rate of COX 2 in cancer tissue was 71.74%, and in normal tissue 32.00%. There were significant difference between renal carcinoma and normal tissues (P<0.01). Conclusion: Expression of COX 2 increases greatly in renal carcinoma. It may be associated with carcinogenesis and as an associate diagnosis predictor of renal carcinoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2004年第3期249-250,共2页
Journal of China Medical University
关键词
肾癌
环氧化酶2
免疫组织化学
renal carcinoma
cyclooxygenase-2
immunohistochemistry
