应用脑电双频指数评估重症病人镇静深度的可行性

Value of bispectral index in assessing the depth of sedation of patients in surgical intensive care unit

目的 :研究应用脑电双频指数 (BIS)评估外科重症监护病房 (SICU)病人镇静深度的可行性。方法 :选择入SICU需呼吸机辅助通气的病人 30例 ,分为 2组 ,均连续监测脉搏 ,心电图 ,血压 ,脉搏血氧饱和度 ,BIS。分别使用微量泵匀速输入咪达唑仑与丙泊酚维持镇静。均使用微量泵匀速输入芬太尼镇痛。每隔 30min用Ramsay评分评估镇静深度 ,用统计学方法计算相关系数 ,比较相关性。结果 :两组相关系数分别为 - 0 .91 ,- 0 .88。两组比较无统计学意义 (P >0 .0 5 )。说明使用不同镇静药时BIS与Ramsay评分均呈负相关 ,且有很好的相关性。并且同一Ramsay评分时BIS值有较小差异 ,呈正态分布。 结论

Objective: To determine the value of the bispectral index (BIS) in assessing the depth of sedation of patients in surgical intensive care unit (SICU). Methods: Thirty patients scheduled for major surgery requiring mechanical ventilation were included. Patients were assigned randomly to receive either midazolam or propofol.Additional analgesic medication was given with fentanyl. The BIS was monitored continuously and Ramsay sedation scale was assessed. Results: The correlation between BIS and Ramsay sedation scale in patients received midazolam or propofol were r =-0.91 and -0.88 respectively. There was no significant difference between these 2 groups of patients(P>0.05). Conclusion: The BIS is suitable for monitoring the depth of sedation of patients in SICU.