P-矩阵法测定安痛定注射液中三组分的含量

Determination of three ingredients in Antongding injection by P-matrix spectrophotometry

目的 :建立安痛定注射液紫外分光光度法的定量分析。方法 :采用 P-矩阵分光光度法测定氨基比林和安替比林 ,采用 P-矩阵法结合吸光度减技术测定巴比妥。结果 :氨基比林 ,安替比林和巴比妥的平均回收率分别为 10 0 .0 % ,10 0 .1%和 10 0 .4 % ,相对标准差分别为 1.6 % ,1.3%和 1.1% (n=6 )。与地方标准方法比较 ,两者测定结果无显著差异。结论 :本法可用于安痛定注射液中三组分的含量测定。

Objective: To establish a quantitative analysis for the Antongding injection by UV spectrophotometry. Method: Aminoprin and Antipyrine was determined by P-matrix spectrophotometry. Barbitial was determined by P-matrix spectrophotometry with absorbance reduction technique. Results: The mean recoveries of Aminopyrin,Antipyrine and Barbitial were 100.0%, 100.1% and 100.4% with RSD 1.6% , 1.3% and 1.1%( n=6 ),respectively. Compared with the standard method,no significant difference was found. Conclusion: Our method can be used for the determination of Aminoprin ,Antipyrine and Barbitial in Antongding injection.