30例慢性肺间质疾病的临床特征

Clinical features and pulmonary function:Analysis of 30 cases of chronic interstitial lung disease

目的 :通过回顾总结 ,提高对慢性肺间质疾病的认识。方法 :回顾性分析 30例慢性肺间质纤维化患者的临床特点和肺功能情况。结果 :30例患者分为两组。特发性肺间质纤维化 (IPF)组 15例 (5 0 % ) ,继发性肺间质纤维化组 15例 (5 0 % )。 IPF组年龄偏大 ;多数有爆裂音 ,占 39.6 % ,杵状指者占 10 .4 % ;CT/ HRCT表现比较典型。两组肺功能改变主要为限制性的通气障碍和弥散功能降低。IPF组肺活量 (VC)和肺总量 (TL C)较继发性组下降明显 (P <0 .0 5 )。结论 :特发性肺间质纤维化和继发性肺间质纤维化的临床特征和肺功能各异。

Objective:To have a deeper understanding of chronic interstitial lung disease. Methods: We retrospectively studied the clinical data and pulmonary function in 30 cases diagnosed interstitial lung disease. Results: In the 30 cases,15 were male and 15 were female,with ages from 30 to 80 years(mean age 66±12). The 30 cases coule be divided into two groups,with 15 cases of idiopathic pulmonary fibrosis(IPF)(50%) in group Ⅰ and 15 cases of secondary interstitial lung disease(SILD) (50%) in GroupⅡ. Age of IPIF group was older than SILD group (P<0.05). Most patients in two groups had crackling sound(39%) and clubbing finger (10.4%) especially with obvious CT/HRCT image . Pulmonary function revealed no significant difference in FEV1 between 2 groups but significantly lower VC and TLC in IPF patients (P<0.05). Conclusions:IPF differs from secondary interstitial lung diseases in clinical features and pulmonary function.